MGP Database

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MGP000118

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 3 family, member A1
Protein EntryAL3A1_HUMAN
UniProt IDP30838
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: Note=Has a high Km for acetaldehyde.;
Catalytic ActivityAn aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
FunctionALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
SimilarityBelongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:22021038}.
Tissue SpecificityHigh levels in stomach, esophagus and lung; low level in the liver and kidney.
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