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MGP000130

Record overview

MGPD IDMGP000130
Gene ID241
SpeciesHomo sapiens (Human)
Gene Namearachidonate 5-lipoxygenase-activating protein
Gene Symbol ALOX5AP
SynonymsFLAP;
Alternate namesarachidonate 5-lipoxygenase-activating protein; MK-886-binding protein;
Chromosome13
Map Location13q12
SummaryThis gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
OrthologsView orthologs and multiple alignments for ALOX5AP

Proteins

arachidonate 5-lipoxygenase-activating protein isoform 1
Refseq ID:NP_001620
Protein GI:15718675
UniProt ID:P20292
mRNA ID:NM_001629
Length:161
RefSeq Status:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVG
YLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
 
arachidonate 5-lipoxygenase-activating protein isoform 2
Refseq ID:NP_001191335
Protein GI:324711029
UniProt ID:P20292
mRNA ID:NM_001204406
Length:218
RefSeq Status:
MLTFNHDAPWHTQKTLKTSEFGKSFGTLGHIGNISHQCWAGCAAGGRAVLSGEPEANMDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQ
RTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDF
ENYIKTISTTISPLLLIP
 
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