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MGP000130

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase-activating protein
Protein EntryAL5AP_HUMAN
UniProt IDP20292
SpeciesHuman
Comments
Comment typeDescription
DiseaseIschemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
DiseaseNote=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269|PubMed:14770184, ECO:0000269|PubMed:17304054}.
DomainThe C-terminal part after residue 140 is mostly unstructured. {ECO:0000269|PubMed:17600184}.
FunctionRequired for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.
SimilarityBelongs to the MAPEG family. {ECO:0000305}.
Subcellular LocationNucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotrimer. Interacts with LTC4S and ALOX5. {ECO:0000269|PubMed:17600184, ECO:0000269|PubMed:19233132}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alox5ap/";
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