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MGP000146

UniProt Annotations

Entry Information
Gene Nameangiopoietin 1
Protein EntryANGP1_HUMAN
UniProt IDQ15389
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15389-1; Sequence=Displayed; Name=2; Synonyms=Gly-269 del; IsoId=Q15389-2; Sequence=VSP_046324;
FunctionBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:9204896}.
MiscellaneousIt may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
PtmGlycosylated.
Sequence CautionSequence=BAA02793.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 fibrinogen C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00739}.
Subcellular LocationSecreted.
SubunitHomooligomer. Interacts with TEK/TIE2. {ECO:0000269|PubMed:12427764, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:9204896}.
Web ResourceName=Wikipedia; Note=Angiopoietin entry; URL="http://en.wikipedia.org/wiki/Angiopoietin";
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