MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000154

UniProt Annotations

Entry Information
Gene Namesolute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Protein EntryADT3_HUMAN
UniProt IDP12236
SpeciesHuman
Comments
Comment typeDescription
FunctionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269|PubMed:15033708}.
InteractionQ5S007:LRRK2; NbExp=2; IntAct=EBI-356254, EBI-5323863;
MiscellaneousThe gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
MiscellaneousThe transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO:0000250}.
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationMitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. {ECO:0000250}.
SubunitFound in a complex with ARL2, ARL2BP and SLC25A6 (By similarity). Homodimer. Interacts with influenza A virus PB1-F2 protein and HIV-1 Vpr. {ECO:0000250, ECO:0000269|PubMed:16120388, ECO:0000269|PubMed:16201016}.
  logo