MGP Database

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MGP000155

UniProt Annotations

Entry Information
Gene Nameannexin A1
Protein EntryANXA1_HUMAN
UniProt IDP04083
SpeciesHuman
Comments
Comment typeDescription
DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
FunctionCalcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
InteractionQ9Y6K9:IKBKG; NbExp=6; IntAct=EBI-354007, EBI-81279; Q13546:RIPK1; NbExp=5; IntAct=EBI-354007, EBI-358507;
PtmPhosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity. {ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:2457390}.
SimilarityBelongs to the annexin family. {ECO:0000305}.
SimilarityContains 4 annexin repeats. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.
SubunitHomodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity). {ECO:0000250}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ANXA1ID653ch9q21.html";
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