MGP Database

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MGP000156

UniProt Annotations

Entry Information
Gene Nameannexin A2
Protein EntryANXA2_HUMAN
UniProt IDP07355
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091;
DomainA pair of annexin repeats may form one binding site for calcium and phospholipid.
FunctionCalcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
InteractionQ99IB8:- (xeno); NbExp=5; IntAct=EBI-352622, EBI-6927873; P40692:MLH1; NbExp=7; IntAct=EBI-352622, EBI-744248; Q8NBP7:PCSK9; NbExp=7; IntAct=EBI-352622, EBI-7539251;
MiscellaneousIt may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
PtmISGylated. {ECO:0000269|PubMed:16139798}.
PtmPhosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. {ECO:0000269|PubMed:15302870, ECO:0000269|PubMed:2946940}.
Sequence CautionSequence=AAH66955.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the annexin family. {ECO:0000305}.
SimilarityContains 4 annexin repeats. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
SubunitHeterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH. {ECO:0000250, ECO:0000269|PubMed:21886777, ECO:0000269|PubMed:8117306}.
Web ResourceName=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/086";
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