MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000167

Ontology/Pathway Information

Entrez Gene ID335
Gene Nameapolipoprotein A-I
Gene Symbol APOA1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0009986 IEA:EnsemblCcell surface
GO:0042627 IBA:GO_CentralCchylomicron
GO:0031410 IDA:BHF-UCLCcytoplasmic vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0034365 IEA:EnsemblCdiscoidal high-density lipoprotein particle
GO:0005769 TAS:ReactomeCearly endosome
GO:0030139 IDA:BHF-UCLCendocytic vesicle
GO:0071682 TAS:ReactomeCendocytic vesicle lumen
GO:0005788 TAS:ReactomeCendoplasmic reticulum lumen
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0034364 IDA:BHF-UCLChigh-density lipoprotein particle
GO:0005634 IEA:EnsemblCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0034774 TAS:ReactomeCsecretory granule lumen
GO:0034366 IDA:BHF-UCLCspherical high-density lipoprotein particle
GO:0034361 IDA:BHF-UCLCvery-low-density lipoprotein particle
GO:0031982 IDA:UniProtKBCvesicle
GO:0034191 IPI:BHF-UCLFapolipoprotein A-I receptor binding
GO:0034190 IPI:BHF-UCLFapolipoprotein receptor binding
GO:0001540 IDA:BHF-UCLFbeta-amyloid binding
GO:0045499 IDA:UniProtKBFchemorepellent activity
GO:0015485 IDA:BHF-UCLFcholesterol binding
GO:0017127 IMP:BHF-UCLFcholesterol transporter activity
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0008035 IEA:EnsemblFhigh-density lipoprotein particle binding
GO:0070653 IPI:BHF-UCLFhigh-density lipoprotein particle receptor binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0055102 IEA:EnsemblFlipase inhibitor activity
GO:0031210 IBA:GO_CentralFphosphatidylcholine binding
GO:0060228 IDA:BHF-UCLFphosphatidylcholine-sterol O-acyltransferase activator activity
GO:0005543 IDA:BHF-UCLFphospholipid binding
GO:0005548 IEA:EnsemblFphospholipid transporter activity
GO:0030325 IEA:EnsemblPadrenal gland development
GO:0007596 TAS:ReactomePblood coagulation
GO:0043534 IEA:EnsemblPblood vessel endothelial cell migration
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006695 IBA:GO_CentralPcholesterol biosynthetic process
GO:0033344 IDA:BHF-UCLPcholesterol efflux
GO:0042632 IDA:BHF-UCLPcholesterol homeostasis
GO:0070508 IMP:BHF-UCLPcholesterol import
GO:0008203 IMP:BHF-UCLPcholesterol metabolic process
GO:0030301 IDA:MGIPcholesterol transport
GO:0001935 IEA:EnsemblPendothelial cell proliferation
GO:0008211 IEA:EnsemblPglucocorticoid metabolic process
GO:0007186 IDA:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0034380 IDA:BHF-UCLPhigh-density lipoprotein particle assembly
GO:0034384 IC:BHF-UCLPhigh-density lipoprotein particle clearance
GO:0034375 IC:BHF-UCLPhigh-density lipoprotein particle remodeling
GO:0007229 IDA:UniProtKBPintegrin-mediated signaling pathway
GO:0019915 IEA:EnsemblPlipid storage
GO:0042158 IEA:EnsemblPlipoprotein biosynthetic process
GO:0042157 IBA:GO_CentralPlipoprotein metabolic process
GO:0050919 IDA:UniProtKBPnegative chemotaxis
GO:0060354 IDA:BHF-UCLPnegative regulation of cell adhesion molecule production
GO:0002740 IDA:BHF-UCLPnegative regulation of cytokine secretion involved in immune response
GO:0034115 IDA:BHF-UCLPnegative regulation of heterotypic cell-cell adhesion
GO:0050728 IDA:BHF-UCLPnegative regulation of inflammatory response
GO:0050713 IDA:BHF-UCLPnegative regulation of interleukin-1 beta secretion
GO:0060192 IEA:EnsemblPnegative regulation of lipase activity
GO:0060761 IDA:BHF-UCLPnegative regulation of response to cytokine stimulus
GO:0010804 IDA:BHF-UCLPnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010903 IDA:BHF-UCLPnegative regulation of very-low-density lipoprotein particle remodeling
GO:0031102 IBA:GO_CentralPneuron projection regeneration
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0018206 IDA:UniProtKBPpeptidyl-methionine modification
GO:0014012 IEA:EnsemblPperipheral nervous system axon regeneration
GO:0006656 IDA:BHF-UCLPphosphatidylcholine biosynthetic process
GO:0033700 IDA:BHF-UCLPphospholipid efflux
GO:0055091 IDA:BHF-UCLPphospholipid homeostasis
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0010873 IDA:BHF-UCLPpositive regulation of cholesterol esterification
GO:0045723 IBA:GO_CentralPpositive regulation of fatty acid biosynthetic process
GO:0051345 IDA:BHF-UCLPpositive regulation of hydrolase activity
GO:0051006 IBA:GO_CentralPpositive regulation of lipoprotein lipase activity
GO:0035025 IDA:UniProtKBPpositive regulation of Rho protein signal transduction
GO:0051496 IDA:UniProtKBPpositive regulation of stress fiber assembly
GO:1900026 IDA:UniProtKBPpositive regulation of substrate adhesion-dependent cell spreading
GO:0051347 IEA:EnsemblPpositive regulation of transferase activity
GO:0010898 IBA:GO_CentralPpositive regulation of triglyceride catabolic process
GO:0018158 IDA:UniProtKBPprotein oxidation
GO:0050821 IDA:BHF-UCLPprotein stabilization
GO:0032489 IDA:BHF-UCLPregulation of Cdc42 protein signal transduction
GO:0030300 IBA:GO_CentralPregulation of intestinal cholesterol absorption
GO:0001932 IEA:EnsemblPregulation of protein phosphorylation
GO:0042493 IEA:EnsemblPresponse to drug
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0007584 IEA:EnsemblPresponse to nutrient
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0043691 IMP:BHF-UCLPreverse cholesterol transport
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0055085 TAS:ReactomePtransmembrane transport
GO:0070328 IDA:BHF-UCLPtriglyceride homeostasis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111158ABCA transporters in lipid homeostasis
REACT_15480ABC-family proteins mediated transport
REACT_75925Amyloids
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_6841Chylomicron-mediated lipid transport
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_13621HDL-mediated lipid transport
REACT_604Hemostasis
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_24968Retinoid metabolism and transport
REACT_163699Scavenging by Class A Receptors
REACT_163679Scavenging by Class B Receptors
REACT_160163Scavenging of heme from plasma
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
REACT_160125Visual phototransduction
  logo