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MGP000168

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-II
Protein EntryAPOA2_HUMAN
UniProt IDP02652
SpeciesHuman
Comments
Comment typeDescription
FunctionMay stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Mass SpectrometryMass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer.; Evidence={ECO:0000269|PubMed:12562854};
Mass SpectrometryMass=17252; Method=Electrospray; Range=24-100; Note=Homodimer, without methionine sulfoxide.; Evidence={ECO:0000269|PubMed:12576517};
Mass SpectrometryMass=17269; Method=Electrospray; Range=24-100; Note=Homodimer, with 1 methionine sulfoxide, oxidation at Met-49.; Evidence={ECO:0000269|PubMed:12576517};
Mass SpectrometryMass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with truncated apolipoprotein A-II.; Evidence={ECO:0000269|PubMed:12562854};
Mass SpectrometryMass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer.; Evidence={ECO:0000269|PubMed:12562854};
Mass SpectrometryMass=8578.3; Method=MALDI; Range=24-99; Evidence={ECO:0000269|PubMed:12562854};
Mass SpectrometryMass=8701.2; Method=MALDI; Range=24-100; Evidence={ECO:0000269|PubMed:12562854};
Mass SpectrometryMass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II.; Evidence={ECO:0000269|PubMed:12562854};
PolymorphismA homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIM:107670].
PtmApolipoprotein A-II is O-glycosylated. {ECO:0000269|PubMed:23234360}.
PtmPhosphorylation sites are present in the extracellular medium. {ECO:0000269|PubMed:19824718}.
SimilarityBelongs to the apolipoprotein A2 family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer; disulfide-linked. Also forms a disulfide- linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1. {ECO:0000269|PubMed:11991719, ECO:0000269|PubMed:12269810, ECO:0000269|PubMed:15922294}.
Tissue SpecificityPlasma; synthesized in the liver and intestine.
Web ResourceName=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2";
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