MGP Database

MGP000172

Record overview

MGPD IDMGP000172
Gene ID344
SpeciesHomo sapiens (Human)
Gene Nameapolipoprotein C-II
Gene Symbol APOC2
SynonymsAPO-CII; APOC-II;
Alternate namesapolipoprotein C-II; apolipoprotein C2;
Chromosome19
Map Location19q13.2
SummaryThis gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
OrthologsView orthologs and multiple alignments for APOC2

Proteins

apolipoprotein C-II precursor
Refseq ID:NP_000474
Protein GI:32130518
UniProt ID:P02655
mRNA ID:NM_000483
Length:101
RefSeq Status:
MGTRLLPALFLVLLVLGFEVQGTQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGE
E
 
sig_peptide: 1..22
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02655.1)
calculated_mol_wt: 2387
peptide sequence: 
MGTRLLPALFLVLLVLGFEVQG

mat_peptide: 23..101
product: Apolipoprotein C-II
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02655.1)
calculated_mol_wt: 8915
peptide sequence: 
TQQPQQDEMPSPTFLTQVKESLSSYWESAKTAAQNLYEKTYLPAVDEKLRDLYSKSTAAMSTYTGIFTDQVLSVLKGEE
 
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