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MGP000172

UniProt Annotations

Entry Information
Gene Nameapolipoprotein C-II
Protein EntryAPOC2_HUMAN
UniProt IDP02655
SpeciesHuman
Comments
Comment typeDescription
DiseaseHyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. {ECO:0000269|PubMed:8323539}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionComponent of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. {ECO:0000269|PubMed:2209608, ECO:0000303|PubMed:22304839}.
PtmProapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing. {ECO:0000269|PubMed:3525527}.
PtmProapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma. {ECO:0000269|PubMed:3525527}.
SimilarityBelongs to the apolipoprotein C2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:3525527}.
Tissue SpecificityLiver and intestine. {ECO:0000269|PubMed:6546757}.
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