MGP Database

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MGP000175

Record overview

MGPD IDMGP000175
Gene ID348
SpeciesHomo sapiens (Human)
Gene Nameapolipoprotein E
Gene Symbol APOE
SynonymsAD2; LPG; APO-E; LDLCQ5;
Alternate namesapolipoprotein E; apolipoprotein E3;
Chromosome19
Map Location19q13.2
SummaryThe protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
OrthologsView orthologs and multiple alignments for APOE

Proteins

apolipoprotein E isoform a precursor
Refseq ID:NP_001289617
Protein GI:705044002
UniProt ID:
mRNA ID:NM_001302688
Length:343
RefSeq Status:
MSSGASRKSWDPGNPWPPDWPITGRKMKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQV
TQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQ
KRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEA
FQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..44
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4829
peptide sequence: 
MSSGASRKSWDPGNPWPPDWPITGRKMKVLWAALLVTFLAGCQA
 
apolipoprotein E isoform b precursor
Refseq ID:NP_000032
Protein GI:4557325
UniProt ID:P02649
mRNA ID:NM_000041
Length:317
RefSeq Status:
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQL
TPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLG
PLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
 
apolipoprotein E isoform b precursor
Refseq ID:NP_001289619
Protein GI:705044104
UniProt ID:
mRNA ID:NM_001302690
Length:317
RefSeq Status:
Protein sequence is identical to GI:4557325 (mRNA isoform)
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
 
apolipoprotein E isoform b precursor
Refseq ID:NP_001289620
Protein GI:705044152
UniProt ID:
mRNA ID:NM_001302691
Length:317
RefSeq Status:
Protein sequence is identical to GI:4557325 (mRNA isoform)
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..44
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 4829
peptide sequence: 
MSSGASRKSWDPGNPWPPDWPITGRKMKVLWAALLVTFLAGCQA

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
 
apolipoprotein E isoform b precursor
Refseq ID:NP_001289618
Protein GI:705044063
UniProt ID:
mRNA ID:NM_001302689
Length:317
RefSeq Status:
Protein sequence is identical to GI:4557325 (mRNA isoform)
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1935
peptide sequence: 
MKVLWAALLVTFLAGCQA

mat_peptide: 19..317
product: Apolipoprotein E
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P02649.1)
calculated_mol_wt: 34237
peptide sequence: 
KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAA
QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAG
QPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
 
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