MGP Database

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MGP000175

Ontology/Pathway Information

Entrez Gene ID348
Gene Nameapolipoprotein E
Gene Symbol APOE
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0042627 IDA:BHF-UCLCchylomicron
GO:0005737 TAS:UniProtKBCcytoplasm
GO:0030425 NAS:BHF-UCLCdendrite
GO:0034365 IEA:EnsemblCdiscoidal high-density lipoprotein particle
GO:0005769 TAS:ReactomeCearly endosome
GO:0071682 TAS:ReactomeCendocytic vesicle lumen
GO:0005783 IEA:EnsemblCendoplasmic reticulum
GO:0031012 IDA:UniProtKBCextracellular matrix
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031232 IEA:EnsemblCextrinsic component of external side of plasma membrane
GO:0005794 IEA:EnsemblCGolgi apparatus
GO:0034364 IDA:BHF-UCLChigh-density lipoprotein particle
GO:0034363 IDA:BHF-UCLCintermediate-density lipoprotein particle
GO:0005770 IEA:EnsemblClate endosome
GO:0034362 IDA:BHF-UCLClow-density lipoprotein particle
GO:0005764 IEA:EnsemblClysosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005874 IEA:EnsemblCmicrotubule
GO:0043025 NAS:BHF-UCLCneuronal cell body
GO:0005635 IEA:EnsemblCnuclear envelope
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0034361 IDA:BHF-UCLCvery-low-density lipoprotein particle
GO:0031982 IDA:UniProtKBCvesicle
GO:0016209 IDA:BHF-UCLFantioxidant activity
GO:0001540 IDA:UniProtKBFbeta-amyloid binding
GO:0015485 IBA:GO_CentralFcholesterol binding
GO:0017127 IBA:GO_CentralFcholesterol transporter activity
GO:0008201 IDA:BHF-UCLFheparin binding
GO:0046848 IEA:EnsemblFhydroxyapatite binding
GO:0042802 IDA:BHF-UCLFidentical protein binding
GO:0008289 IDA:UniProtKBFlipid binding
GO:0005319 IDA:BHF-UCLFlipid transporter activity
GO:0071813 IEA:EnsemblFlipoprotein particle binding
GO:0050750 IDA:BHF-UCLFlow-density lipoprotein particle receptor binding
GO:0046911 IDA:BHF-UCLFmetal chelating activity
GO:0060228 IDA:BHF-UCLFphosphatidylcholine-sterol O-acyltransferase activator activity
GO:0005543 IDA:BHF-UCLFphospholipid binding
GO:0042803 IPI:BHF-UCLFprotein homodimerization activity
GO:0048156 IPI:BHF-UCLFtau protein binding
GO:0070326 IDA:BHF-UCLFvery-low-density lipoprotein particle receptor binding
GO:0007568 IEA:EnsemblPaging
GO:0097113 IDA:Alzheimers_University_of_TorontoPalpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0048844 IEA:EnsemblPartery morphogenesis
GO:0006874 IEA:EnsemblPcellular calcium ion homeostasis
GO:0071397 IEA:EnsemblPcellular response to cholesterol
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0071347 IEA:EnsemblPcellular response to interleukin-1
GO:0019934 IDA:BHF-UCLPcGMP-mediated signaling
GO:0006707 IBA:GO_CentralPcholesterol catabolic process
GO:0033344 IDA:BHF-UCLPcholesterol efflux
GO:0042632 IDA:BHF-UCLPcholesterol homeostasis
GO:0008203 IDA:BHF-UCLPcholesterol metabolic process
GO:0034382 IMP:BHF-UCLPchylomicron remnant clearance
GO:0007010 TAS:UniProtKBPcytoskeleton organization
GO:0055089 IDA:Alzheimers_University_of_TorontoPfatty acid homeostasis
GO:0007186 IDA:BHF-UCLPG-protein coupled receptor signaling pathway
GO:0034380 IDA:BHF-UCLPhigh-density lipoprotein particle assembly
GO:0034384 IDA:BHF-UCLPhigh-density lipoprotein particle clearance
GO:0034375 IGI:BHF-UCLPhigh-density lipoprotein particle remodeling
GO:0046907 TAS:UniProtKBPintracellular transport
GO:0042158 IEA:EnsemblPlipoprotein biosynthetic process
GO:0042159 IBA:GO_CentralPlipoprotein catabolic process
GO:0042157 TAS:ReactomePlipoprotein metabolic process
GO:0015909 IDA:Alzheimers_University_of_TorontoPlong-chain fatty acid transport
GO:0034374 IEA:EnsemblPlow-density lipoprotein particle remodeling
GO:0051651 IEA:EnsemblPmaintenance of location in cell
GO:1902430 IDA:Alzheimers_University_of_TorontoPnegative regulation of beta-amyloid formation
GO:0030195 IDA:BHF-UCLPnegative regulation of blood coagulation
GO:0043537 IDA:BHF-UCLPnegative regulation of blood vessel endothelial cell migration
GO:0045541 IDA:BHF-UCLPnegative regulation of cholesterol biosynthetic process
GO:0090370 IDA:Alzheimers_University_of_TorontoPnegative regulation of cholesterol efflux
GO:0061000 IDA:Alzheimers_University_of_TorontoPnegative regulation of dendritic spine development
GO:1902951 IDA:Alzheimers_University_of_TorontoPnegative regulation of dendritic spine maintenance
GO:0001937 IDA:BHF-UCLPnegative regulation of endothelial cell proliferation
GO:0050728 IC:BHF-UCLPnegative regulation of inflammatory response
GO:0051055 IDA:Alzheimers_University_of_TorontoPnegative regulation of lipid biosynthetic process
GO:1903001 IDA:Alzheimers_University_of_TorontoPnegative regulation of lipid transport across blood brain barrier
GO:0043407 IDA:BHF-UCLPnegative regulation of MAP kinase activity
GO:0043524 IBA:GO_CentralPnegative regulation of neuron apoptotic process
GO:1901215 IDA:Alzheimers_University_of_TorontoPnegative regulation of neuron death
GO:1902999 IDA:Alzheimers_University_of_TorontoPnegative regulation of phospholipid efflux
GO:0010544 IDA:BHF-UCLPnegative regulation of platelet activation
GO:1901627 IDA:Alzheimers_University_of_TorontoPnegative regulation of postsynaptic membrane organization
GO:1901630 IDA:Alzheimers_University_of_TorontoPnegative regulation of presynaptic membrane organization
GO:0031102 IBA:GO_CentralPneuron projection regeneration
GO:0007263 IDA:BHF-UCLPnitric oxide mediated signal transduction
GO:0097114 IDA:Alzheimers_University_of_TorontoPN-methyl-D-aspartate receptor clustering
GO:0048709 IEA:EnsemblPoligodendrocyte differentiation
GO:0014012 IEA:EnsemblPperipheral nervous system axon regeneration
GO:0033700 IDA:BHF-UCLPphospholipid efflux
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0045773 IEA:EnsemblPpositive regulation of axon extension
GO:1902004 IDA:Alzheimers_University_of_TorontoPpositive regulation of beta-amyloid formation
GO:0030828 IDA:BHF-UCLPpositive regulation of cGMP biosynthetic process
GO:0010875 IDA:Alzheimers_University_of_TorontoPpositive regulation of cholesterol efflux
GO:0010873 IDA:BHF-UCLPpositive regulation of cholesterol esterification
GO:0060999 IDA:Alzheimers_University_of_TorontoPpositive regulation of dendritic spine development
GO:1902952 IDA:Alzheimers_University_of_TorontoPpositive regulation of dendritic spine maintenance
GO:0046889 IDA:Alzheimers_University_of_TorontoPpositive regulation of lipid biosynthetic process
GO:1903002 IDA:Alzheimers_University_of_TorontoPpositive regulation of lipid transport across blood brain barrier
GO:0032805 IDA:BHF-UCLPpositive regulation of low-density lipoprotein particle receptor catabolic process
GO:0051044 IDA:BHF-UCLPpositive regulation of membrane protein ectodomain proteolysis
GO:1902998 IDA:Alzheimers_University_of_TorontoPpositive regulation of neurofibrillary tangle assembly
GO:1901216 IDA:Alzheimers_University_of_TorontoPpositive regulation of neuron death
GO:0051000 IDA:BHF-UCLPpositive regulation of nitric-oxide synthase activity
GO:1902995 IDA:Alzheimers_University_of_TorontoPpositive regulation of phospholipid efflux
GO:1901628 IDA:Alzheimers_University_of_TorontoPpositive regulation of postsynaptic membrane organization
GO:1901631 IDA:Alzheimers_University_of_TorontoPpositive regulation of presynaptic membrane organization
GO:0017038 IDA:Alzheimers_University_of_TorontoPprotein import
GO:0006898 IDA:BHF-UCLPreceptor-mediated endocytosis
GO:0030516 TAS:UniProtKBPregulation of axon extension
GO:1900221 IDA:Alzheimers_University_of_TorontoPregulation of beta-amyloid clearance
GO:0032489 IDA:BHF-UCLPregulation of Cdc42 protein signal transduction
GO:0010468 IEA:EnsemblPregulation of gene expression
GO:0048168 TAS:UniProtKBPregulation of neuronal synaptic plasticity
GO:1901214 IDA:Alzheimers_University_of_TorontoPregulation of neuron death
GO:1902947 IDA:Alzheimers_University_of_TorontoPregulation of tau-protein kinase activity
GO:0002021 IEA:EnsemblPresponse to dietary excess
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0032868 IEA:EnsemblPresponse to insulin
GO:0000302 NAS:UniProtKBPresponse to reactive oxygen species
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0001523 TAS:ReactomePretinoid metabolic process
GO:0043691 IDA:BHF-UCLPreverse cholesterol transport
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007271 TAS:UniProtKBPsynaptic transmission, cholinergic
GO:0019433 IBA:GO_CentralPtriglyceride catabolic process
GO:0006641 IDA:BHF-UCLPtriglyceride metabolic process
GO:0042311 IEA:EnsemblPvasodilation
GO:0034447 IDA:BHF-UCLPvery-low-density lipoprotein particle clearance
GO:0034372 IDA:BHF-UCLPvery-low-density lipoprotein particle remodeling
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_6841Chylomicron-mediated lipid transport
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_13621HDL-mediated lipid transport
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_24968Retinoid metabolism and transport
REACT_163699Scavenging by Class A Receptors
REACT_111102Signal Transduction
REACT_160125Visual phototransduction
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