MGP Database

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MGP000176

Ontology/Pathway Information

Entrez Gene ID351
Gene Nameamyloid beta (A4) precursor protein
Gene Symbol APP
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0030424 ISS:UniProtKBCaxon
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0009986 IDA:UniProtKBCcell surface
GO:0035253 IEA:EnsemblCciliary rootlet
GO:0005905 IEA:UniProtKB-SubCellCcoated pit
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0043198 IDA:MGICdendritic shaft
GO:0043197 IDA:MGICdendritic spine
GO:0005768 IDA:UniProtKBCendosome
GO:0030134 IEA:EnsemblCER to Golgi transport vesicle
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005794 IDA:UniProtKBCGolgi apparatus
GO:0016021 ISS:UniProtKBCintegral component of membrane
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0045121 IDA:ParkinsonsUK-UCLCmembrane raft
GO:0031594 IEA:EnsemblCneuromuscular junction
GO:0005641 IDA:Alzheimers_University_of_TorontoCnuclear envelope lumen
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0043235 IDA:MGICreceptor complex
GO:0051233 IEA:EnsemblCspindle midzone
GO:0045202 IDA:MGICsynapse
GO:0033130 IPI:UniProtKBFacetylcholine receptor binding
GO:0003677 ISS:UniProtKBFDNA binding
GO:0019899 IPI:ParkinsonsUK-UCLFenzyme binding
GO:0008201 IEA:UniProtKB-KWFheparin binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0016504 IEA:EnsemblFpeptidase activator activity
GO:0051425 IPI:BHF-UCLFPTB domain binding
GO:0005102 IPI:BHF-UCLFreceptor binding
GO:0004867 IDA:UniProtKBFserine-type endopeptidase inhibitor activity
GO:0046914 IEA:InterProFtransition metal ion binding
GO:0008344 ISS:UniProtKBPadult locomotory behavior
GO:0008088 ISS:UniProtKBPaxon cargo transport
GO:0016199 ISS:UniProtKBPaxon midline choice point recognition
GO:0007409 ISS:UniProtKBPaxonogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 IEA:UniProtKB-KWPcell adhesion
GO:0006878 ISS:UniProtKBPcellular copper ion homeostasis
GO:0008203 IEA:EnsemblPcholesterol metabolic process
GO:0048669 ISS:UniProtKBPcollateral sprouting in absence of injury
GO:0016358 ISS:UniProtKBPdendrite development
GO:0006897 ISS:UniProtKBPendocytosis
GO:0030198 ISS:UniProtKBPextracellular matrix organization
GO:0030900 IEA:EnsemblPforebrain development
GO:0045087 TAS:ReactomePinnate immune response
GO:0035235 ISS:UniProtKBPionotropic glutamate receptor signaling pathway
GO:0007626 ISS:UniProtKBPlocomotory behavior
GO:0007617 ISS:UniProtKBPmating behavior
GO:0006378 ISS:UniProtKBPmRNA polyadenylation
GO:0010951 IDA:GOCPnegative regulation of endopeptidase activity
GO:0045665 IEA:EnsemblPnegative regulation of neuron differentiation
GO:0050885 IEA:EnsemblPneuromuscular process controlling balance
GO:0051402 IMP:UniProtKBPneuron apoptotic process
GO:0031175 ISS:UniProtKBPneuron projection development
GO:0016322 ISS:UniProtKBPneuron remodeling
GO:0007219 IEA:UniProtKB-KWPNotch signaling pathway
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0010971 IEA:EnsemblPpositive regulation of G2/M transition of mitotic cell cycle
GO:0045931 ISS:UniProtKBPpositive regulation of mitotic cell cycle
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0006468 ISS:UniProtKBPprotein phosphorylation
GO:0007176 ISS:UniProtKBPregulation of epidermal growth factor-activated receptor activity
GO:0040014 ISS:UniProtKBPregulation of multicellular organism growth
GO:0043393 IEA:EnsemblPregulation of protein binding
GO:0050803 ISS:UniProtKBPregulation of synapse structure and activity
GO:0006417 ISS:UniProtKBPregulation of translation
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0051563 IEA:EnsemblPsmooth endoplasmic reticulum calcium ion homeostasis
GO:0001967 IEA:EnsemblPsuckling behavior
GO:0051124 IEA:EnsemblPsynaptic growth at neuromuscular junction
GO:0008542 ISS:UniProtKBPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_75925Amyloids
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_116125Disease
REACT_163906ECM proteoglycans
REACT_118779Extracellular matrix organization
REACT_21264Formyl peptide receptors bind formyl peptides and many other ligands
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_604Hemostasis
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_14819Peptide ligand-binding receptors
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_75808The NLRP3 inflammasome
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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