MGP Database

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MGP000181

Record overview

MGPD IDMGP000181
Gene ID358
SpeciesHomo sapiens (Human)
Gene Nameaquaporin 1 (Colton blood group)
Gene Symbol AQP1
SynonymsCO; CHIP28; AQP-CHIP;
Alternate namesaquaporin-1; aquaporin-CHIP; urine water channel; channel-like integral membrane protein, 28-kDa; water channel protein for red blood cells and kidney proximal tubule; aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group);
Chromosome7
Map Location7p14
SummaryAquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
OrthologsView orthologs and multiple alignments for AQP1

Proteins

aquaporin-1 isoform 1
Refseq ID:NP_932766
Protein GI:37694062
UniProt ID:P29972
mRNA ID:NM_198098
Length:269
RefSeq Status:
MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIA
QCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSA
VITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
 
aquaporin-1 isoform 2
Refseq ID:NP_001171989
Protein GI:297307116
UniProt ID:P29972
mRNA ID:NM_001185060
Length:186
RefSeq Status:
MPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLA
IDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
 
aquaporin-1 isoform 3
Refseq ID:NP_001171990
Protein GI:297307118
UniProt ID:P29972
mRNA ID:NM_001185061
Length:218
RefSeq Status:
MFWTFGYEAVSPAGPSHLFASLLLGVLLTITFMPGARPLPLVLVPQNTLAWMQLDAKAPAHPRPLQLLGRVGPGSRQLADGVNSGQGLGIEIIGTLQLVL
CVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVE
EYDLDADDINSRVEMKPK
 
aquaporin-1 isoform 4
Refseq ID:NP_001171991
Protein GI:297307120
UniProt ID:P29972
mRNA ID:NM_001185062
Length:154
RefSeq Status:
MQSGMGWNVLDFWLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVG
PFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
 
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