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MGP000195

Record overview

MGPD IDMGP000195
Gene ID383
SpeciesHomo sapiens (Human)
Gene Namearginase 1
Gene Symbol ARG1
Alternate namesarginase-1; arginase, liver; type I arginase; liver-type arginase;
Chromosome6
Map Location6q23
EC Number3.5.3.1
SummaryArginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for ARG1

Proteins

arginase-1 isoform 1
Refseq ID:NP_001231367
Protein GI:346986435
UniProt ID:P05089
mRNA ID:NM_001244438
Length:330
RefSeq Status:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQVTQNFLILECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGR
ISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKT
LGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRT
VNTAVAITLACFGLAREGNHKPIDYLNPPK
 
arginase-1 isoform 2
Refseq ID:NP_000036
Protein GI:10947139
UniProt ID:P05089
mRNA ID:NM_000045
Length:322
RefSeq Status:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGD
HSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSM
TEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
 
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