MGP Database

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MGP000199

Record overview

MGPD IDMGP000199
Gene ID389
SpeciesHomo sapiens (Human)
Gene Nameras homolog family member C
Gene Symbol RHOC
SynonymsH9; ARH9; ARHC; RHOH9;
Alternate namesrho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; small GTP binding protein RhoC; ras homolog gene family, member C;
Chromosome1
Map Location1p13.1
SummaryThis gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RHOC

Proteins

rho-related GTP-binding protein RhoC precursor
Refseq ID:NP_001036143
Protein GI:111494248
UniProt ID:P08134
mRNA ID:NM_001042678
Length:193
RefSeq Status:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL
 
mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC

mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC

mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC
 
rho-related GTP-binding protein RhoC precursor
Refseq ID:NP_786886
Protein GI:28395033
UniProt ID:P08134
mRNA ID:NM_175744
Length:193
RefSeq Status:
Protein sequence is identical to GI:111494248 (mRNA isoform)
 
mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC
 
rho-related GTP-binding protein RhoC precursor
Refseq ID:NP_001036144
Protein GI:111494251
UniProt ID:P08134
mRNA ID:NM_001042679
Length:193
RefSeq Status:
Protein sequence is identical to GI:111494248 (mRNA isoform)
 
mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC

mat_peptide: 1..190
product: rho-related GTP-binding protein RhoC
calculated_mol_wt: 21683
peptide sequence: 
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWT
PEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGC
 
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