MGP Database

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MGP000199

UniProt Annotations

Entry Information
Gene Nameras homolog family member C
Protein EntryRHOC_HUMAN
UniProt IDP08134
SpeciesHuman
Comments
Comment typeDescription
FunctionRegulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.
SimilarityBelongs to the small GTPase superfamily. Rho family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cleavage furrow {ECO:0000269|PubMed:16236794}. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.
SubunitInteracts with RTKN (By similarity). Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA. {ECO:0000250, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:15864301, ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:8816443}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RHOCID42110ch1p13.html";
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