MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000224

Record overview

MGPD IDMGP000224
Gene ID438
SpeciesHomo sapiens (Human)
Gene Nameacetylserotonin O-methyltransferase
Gene Symbol ASMT
SynonymsASMTY; HIOMT; HIOMTY;
Alternate namesacetylserotonin O-methyltransferase; hydroxyindole O-methyltransferase; acetylserotonin N-methyltransferase; acetylserotonin methyltransferase (Y chromosome);
ChromosomeX
Map LocationXp22.3 or Yp11.3
EC Number2.1.1.4
SummaryThis gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
OrthologsView orthologs and multiple alignments for ASMT

Proteins

acetylserotonin O-methyltransferase isoform 1
Refseq ID:NP_004034
Protein GI:157168360
UniProt ID:P46597
mRNA ID:NM_004043
Length:373
RefSeq Status:
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPT
SQCSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVFPLMCDLGGTWIKLETIILSK
LSQGQKTKHRVFSLIGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLYILARVLHDWADGKCSHLLERIYHT
CKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
 
acetylserotonin O-methyltransferase isoform 1
Refseq ID:NP_001164509
Protein GI:283549144
UniProt ID:P46597
mRNA ID:NM_001171038
Length:373
RefSeq Status:
Protein sequence is identical to GI:157168360 (mRNA isoform)
 
acetylserotonin O-methyltransferase isoform 2
Refseq ID:NP_001164510
Protein GI:283549146
UniProt ID:P46597
mRNA ID:NM_001171039
Length:298
RefSeq Status:
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPT
SQCSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVFPLMCDLGGDFFKDPLPEADL
YILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
 
  logo