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MGP000224

UniProt Annotations

Entry Information
Gene Nameacetylserotonin O-methyltransferase
Protein EntryASMT_HUMAN
UniProt IDP46597
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P46597-1; Sequence=Displayed; Name=2; IsoId=P46597-2; Sequence=VSP_004285; Name=3; IsoId=P46597-3; Sequence=VSP_004284; Note=Includes part of a LINE-1 element. Ref.1 (AAA58582/AAA58583/AAA75290), Ref.2 (AAA17020) and Ref.3 (BAG37430) sequences are in conflict in position: 190:W->R. {ECO:0000305};
Catalytic ActivityS-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. {ECO:0000269|PubMed:22775292}.
FunctionIsoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269|PubMed:22775292}.
InductionBy all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79. {ECO:0000269|PubMed:8752109, ECO:0000269|PubMed:8842389}.
InteractionSelf; NbExp=3; IntAct=EBI-6502097, EBI-6502097;
MiscellaneousThe gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
PathwayAromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01020}.
SubunitHomodimer. {ECO:0000269|PubMed:22775292}.
Tissue SpecificityExpressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269|PubMed:22775292, ECO:0000269|PubMed:7989373, ECO:0000269|PubMed:8574683}.
Web ResourceName=Wikipedia; Note=5-hydroxyindole-O- methyltransferase entry; URL="http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase";
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