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MGP000225

Record overview

MGPD IDMGP000225
Gene ID440
SpeciesHomo sapiens (Human)
Gene Nameasparagine synthetase (glutamine-hydrolyzing)
Gene Symbol ASNS
SynonymsTS11; ASNSD;
Alternate namesasparagine synthetase [glutamine-hydrolyzing]; TS11 cell cycle control protein; glutamine-dependent asparagine synthetase;
Chromosome7
Map Location7q21.3
EC Number6.3.5.4
SummaryThe protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
OrthologsView orthologs and multiple alignments for ASNS

Proteins

asparagine synthetase [glutamine-hydrolyzing] isoform a
Refseq ID:NP_597680
Protein GI:168229248
UniProt ID:P08243
mRNA ID:NM_133436
Length:561
RefSeq Status:
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEI
ILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVE
MVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR
KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLF
DVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMAN
AAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
 
asparagine synthetase [glutamine-hydrolyzing] isoform a
Refseq ID:NP_899199
Protein GI:168229252
UniProt ID:P08243
mRNA ID:NM_183356
Length:561
RefSeq Status:
Protein sequence is identical to GI:168229248 (mRNA isoform)
 
asparagine synthetase [glutamine-hydrolyzing] isoform a
Refseq ID:NP_001664
Protein GI:168229250
UniProt ID:P08243
mRNA ID:NM_001673
Length:561
RefSeq Status:
Protein sequence is identical to GI:168229248 (mRNA isoform)
 
asparagine synthetase [glutamine-hydrolyzing] isoform b
Refseq ID:NP_001171546
Protein GI:296010848
UniProt ID:P08243
mRNA ID:NM_001178075
Length:540
RefSeq Status:
MKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVF
AFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEK
LFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGI
QALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFL
DHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQV
FERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
 
asparagine synthetase [glutamine-hydrolyzing] isoform c
Refseq ID:NP_001171547
Protein GI:296010850
UniProt ID:P08243
mRNA ID:NM_001178076
Length:478
RefSeq Status:
MQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPG
HYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPL
QTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSP
EKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFK
ILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA
 
asparagine synthetase [glutamine-hydrolyzing] isoform c
Refseq ID:NP_001171548
Protein GI:296010852
UniProt ID:P08243
mRNA ID:NM_001178077
Length:478
RefSeq Status:
Protein sequence is identical to GI:296010850 (mRNA isoform)
 
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