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MGP000231

Record overview

MGPD IDMGP000231
Gene ID468
SpeciesHomo sapiens (Human)
Gene Nameactivating transcription factor 4
Gene Symbol ATF4
SynonymsCREB2; TXREB; CREB-2; TAXREB67;
Alternate namescyclic AMP-dependent transcription factor ATF-4; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67;
Chromosome22
Map Location22q13.1
SummaryThis gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for ATF4

Proteins

cyclic AMP-dependent transcription factor ATF-4
Refseq ID:NP_877962
Protein GI:33469974
UniProt ID:P18848
mRNA ID:NM_182810
Length:351
RefSeq Status:
MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSEWLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALL
GIDDLETMPDDLLTTLDDTCDLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSLELGSEVDITEGDRKPDYTAY
VAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRGSPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
 
cyclic AMP-dependent transcription factor ATF-4
Refseq ID:NP_001666
Protein GI:33469976
UniProt ID:P18848
mRNA ID:NM_001675
Length:351
RefSeq Status:
Protein sequence is identical to GI:33469974 (mRNA isoform)
 
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