MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000231

Ontology/Pathway Information

Entrez Gene ID468
Gene Nameactivating transcription factor 4
Gene Symbol ATF4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0032590 IEA:EnsemblCdendrite membrane
GO:1990037 IDA:ParkinsonsUK-UCLCLewy body core
GO:0005815 IEA:UniProtKB-SubCellCmicrotubule organizing center
GO:0043005 IDA:ParkinsonsUK-UCLCneuron projection
GO:0034399 IDA:ParkinsonsUK-UCLCnuclear periphery
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0001046 ISS:UniProtKBFcore promoter sequence-specific DNA binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0000978 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000981 IC:ParkinsonsUK-UCLFsequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 ISS:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0044212 IDA:ParkinsonsUK-UCLFtranscription regulatory region DNA binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0006520 TAS:UniProtKBPcellular amino acid metabolic process
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0007214 IEA:EnsemblPgamma-aminobutyric acid signaling pathway
GO:0006094 ISS:UniProtKBPgluconeogenesis
GO:0070059 ISS:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1903204 IGI:ParkinsonsUK-UCLPnegative regulation of oxidative stress-induced neuron death
GO:0043267 IEA:EnsemblPnegative regulation of potassium ion transport
GO:0043065 TAS:ParkinsonsUK-UCLPpositive regulation of apoptotic process
GO:0043525 ISS:UniProtKBPpositive regulation of neuron apoptotic process
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:1990440 IMP:ParkinsonsUK-UCLPpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0036091 IMP:ParkinsonsUK-UCLPpositive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0006355 ISS:UniProtKBPregulation of transcription, DNA-templated
GO:0034976 IDA:BHF-UCLPresponse to endoplasmic reticulum stress
GO:0006366 ISS:UniProtKBPtranscription from RNA polymerase II promoter
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18355ATF4 activates genes
REACT_18423ATF6-alpha activates chaperone genes
REACT_18348ATF6-alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_18277PERK regulates gene expression
REACT_18356Unfolded Protein Response (UPR)
  logo