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MGP000239

Record overview

MGPD IDMGP000239
Gene ID480
SpeciesHomo sapiens (Human)
Gene NameATPase, Na+/K+ transporting, alpha 4 polypeptide
Gene Symbol ATP1A4
SynonymsATP1A1; ATP1AL2;
Alternate namessodium/potassium-transporting ATPase subunit alpha-4; sodium pump 4; Na+/K+ ATPase 4; Na,K-ATPase subunit alpha-C; sodium pump subunit alpha-4; Na(+)/K(+) ATPase alpha-4 subunit; Na+/K+ ATPase, alpha-D polypeptide; sodium-potassium ATPase catalytic subunit alpha-4; sodium/potassium-transporting ATPase alpha-4 chain; ATPase, Na+/K+ transporting, alpha polypeptide-like 2;
Chromosome1
Map Location1q23.2
EC Number3.6.3.9
SummaryThe protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ATP1A4

Proteins

sodium/potassium-transporting ATPase subunit alpha-4 isoform 1
Refseq ID:NP_653300
Protein GI:153946397
UniProt ID:Q13733
mRNA ID:NM_144699
Length:1029
RefSeq Status:
MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKF
CKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVE
IKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFI
HLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW
FDMTVYEADTTEEQTGKTFTKSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVAEIPFNSTNKYQMSI
HLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDP
PRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTS
PQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFI
ILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKY
LNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPY
SILIFVYDEIRKLLIRQHPDGWVERETYY
 
sodium/potassium-transporting ATPase subunit alpha-4 isoform 2
Refseq ID:NP_001001734
Protein GI:49249977
UniProt ID:Q13733
mRNA ID:NM_001001734
Length:165
RefSeq Status:
MIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGI
LEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPDGWVERETYY
 
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