MGP Database

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MGP000239

UniProt Annotations

Entry Information
Gene NameATPase, Na+/K+ transporting, alpha 4 polypeptide
Protein EntryAT1A4_HUMAN
UniProt IDQ13733
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13733-1; Sequence=Displayed; Name=2; IsoId=Q13733-2; Sequence=VSP_007364; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
Enzyme RegulationSpecifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000269|PubMed:16175638}.
FunctionThis is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Sequence CautionSequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:16175638}; Multi-pass membrane protein {ECO:0000269|PubMed:16175638}. Note=In mature sperm, located in the principle piece of the sperm flagellum.
SubunitComposed of three subunits: alpha (catalytic), beta and gamma.
Tissue SpecificitySpecifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).
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