MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000240

UniProt Annotations

Entry Information
Gene NameATPase, Na+/K+ transporting, beta 1 polypeptide
Protein EntryAT1B1_HUMAN
UniProt IDP05026
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05026-1; Sequence=Displayed; Name=2; IsoId=P05026-2; Sequence=VSP_000349;
DomainThe C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties. {ECO:0000250}.
FunctionInvolved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269|PubMed:19694409}.
FunctionThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO:0000269|PubMed:19694409}.
SimilarityBelongs to the X(+)/potassium ATPases subunit beta family. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass type II membrane protein.
SubunitComposed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM. {ECO:0000250, ECO:0000269|PubMed:22328087}.
Tissue SpecificityFound in most tissues.
  logo