MGP Database

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MGP000242

UniProt Annotations

Entry Information
Gene NameATPase, Na+/K+ transporting, beta 3 polypeptide
Protein EntryAT1B3_HUMAN
UniProt IDP54709
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54709-1; Sequence=Displayed; Name=2; IsoId=P54709-2; Sequence=VSP_056686, VSP_056687; Note=No experimental confirmation available.;
DomainThe C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties. {ECO:0000250}.
FunctionThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
SimilarityBelongs to the X(+)/potassium ATPases subunit beta family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitComposed of three subunits: alpha (catalytic), beta and gamma.
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