MGP Database

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MGP000293

UniProt Annotations

Entry Information
Gene Namebranched chain amino-acid transaminase 2, mitochondrial
Protein EntryBCAT2_HUMAN
UniProt IDO15382
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=A; IsoId=O15382-1; Sequence=Displayed; Name=B; IsoId=O15382-2; Sequence=VSP_000236;
Catalytic ActivityL-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate.
Catalytic ActivityL-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate.
Catalytic ActivityL-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCatalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
Sequence CautionSequence=AAB53087.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationIsoform A: Mitochondrion.
Subcellular LocationIsoform B: Cytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:11264579}.
Tissue SpecificityUbiquitous.
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