MGP Database

MGP000297

Ontology/Pathway Information

Entrez Gene ID	595
Gene Name	cyclin D1
Gene Symbol	CCND1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0000307	IDA:BHF-UCL	C	cyclin-dependent protein kinase holoenzyme complex
GO:0005829	TAS:Reactome	C	cytosol
GO:0005622	IDA:LIFEdb	C	intracellular
GO:0016020	IEA:UniProtKB-SubCell	C	membrane
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0005923	IEA:Ensembl	C	tight junction
GO:0017053	IDA:UniProtKB	C	transcriptional repressor complex
GO:0016538	IEA:Ensembl	F	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899	IPI:UniProtKB	F	enzyme binding
GO:0042826	IPI:UniProtKB	F	histone deacetylase binding
GO:0070064	IDA:UniProtKB	F	proline-rich region binding
GO:0004672	IEA:Ensembl	F	protein kinase activity
GO:0019901	IPI:UniProtKB	F	protein kinase binding
GO:0003714	IDA:UniProtKB	F	transcription corepressor activity
GO:0008134	IPI:UniProtKB	F	transcription factor binding
GO:0060070	IEA:Ensembl	P	canonical Wnt signaling pathway
GO:0051301	IEA:UniProtKB-KW	P	cell division
GO:0006974	IDA:UniProtKB	P	cellular response to DNA damage stimulus
GO:0030968	IEA:Ensembl	P	endoplasmic reticulum unfolded protein response
GO:0045444	IEA:Ensembl	P	fat cell differentiation
GO:0000082	IDA:UniProtKB	P	G1/S transition of mitotic cell cycle
GO:0007595	IEA:Ensembl	P	lactation
GO:0033327	IEA:Ensembl	P	Leydig cell differentiation
GO:0001889	IEA:Ensembl	P	liver development
GO:0060749	IEA:Ensembl	P	mammary gland alveolus development
GO:0033598	IEA:Ensembl	P	mammary gland epithelial cell proliferation
GO:0000278	TAS:Reactome	P	mitotic cell cycle
GO:0031571	IDA:UniProtKB	P	mitotic G1 DNA damage checkpoint
GO:0071157	IDA:UniProtKB	P	negative regulation of cell cycle arrest
GO:0030857	IEA:Ensembl	P	negative regulation of epithelial cell differentiation
GO:0000122	IDA:UniProtKB	P	negative regulation of transcription from RNA polymerase II promoter
GO:0030178	IEA:Ensembl	P	negative regulation of Wnt signaling pathway
GO:0007219	TAS:Reactome	P	Notch signaling pathway
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0045737	IDA:BHF-UCL	P	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0010971	IDA:UniProtKB	P	positive regulation of G2/M transition of mitotic cell cycle
GO:0033601	IEA:Ensembl	P	positive regulation of mammary gland epithelial cell proliferation
GO:0001934	IDA:BHF-UCL	P	positive regulation of protein phosphorylation
GO:0000320	IEA:Ensembl	P	re-entry into mitotic cell cycle
GO:0051592	IEA:Ensembl	P	response to calcium ion
GO:0051412	IEA:Ensembl	P	response to corticosterone
GO:0042493	IEP:UniProtKB	P	response to drug
GO:0043627	IEA:Ensembl	P	response to estrogen
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0010039	IEA:Ensembl	P	response to iron ion
GO:0032026	IEA:Ensembl	P	response to magnesium ion
GO:0010243	IEA:Ensembl	P	response to organonitrogen compound
GO:0070141	IDA:BHF-UCL	P	response to UV-A
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0010165	IEA:Ensembl	P	response to X-ray
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_115566	Cell Cycle
REACT_152	Cell Cycle, Mitotic
REACT_264165	Chromatin modifying enzymes
REACT_264155	Chromatin organization
REACT_821	Cyclin D associated events in G1
REACT_1590	G1 Phase
REACT_21267	Mitotic G1-G1/S phases
REACT_118744	Pre-NOTCH Expression and Processing
REACT_118568	Pre-NOTCH Transcription and Translation
REACT_264545	RMTs methylate histone arginines
REACT_299	Signaling by NOTCH
REACT_111102	Signal Transduction
REACT_899	S Phase
REACT_938	Ubiquitin-dependent degradation of Cyclin D
REACT_4	Ubiquitin-dependent degradation of Cyclin D1