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MGP000298

Record overview

MGPD IDMGP000298
Gene ID596
SpeciesHomo sapiens (Human)
Gene NameB-cell CLL/lymphoma 2
Gene Symbol BCL2
SynonymsBcl-2; PPP1R50;
Alternate namesapoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50;
Chromosome18
Map Location18q21.3
SummaryThis gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BCL2

Proteins

apoptosis regulator Bcl-2 alpha isoform
Refseq ID:NP_000624
Protein GI:72198189
UniProt ID:P10415
mRNA ID:NM_000633
Length:239
RefSeq Status:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQA
GDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVE
LYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
 
apoptosis regulator Bcl-2 beta isoform
Refseq ID:NP_000648
Protein GI:72198346
UniProt ID:P10415
mRNA ID:NM_000657
Length:205
RefSeq Status:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQA
GDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGALG
DVSLG
 
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