MGP Database

MGP000298

Ontology/Pathway Information

Entrez Gene ID	596
Gene Name	B-cell CLL/lymphoma 2
Gene Symbol	BCL2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	IEA:UniProtKB-SubCell	C	endoplasmic reticulum membrane
GO:0016020	IDA:MGI	C	membrane
GO:0005741	IDA:UniProtKB	C	mitochondrial outer membrane
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0043209	IEA:Ensembl	C	myelin sheath
GO:0031965	IDA:UniProtKB	C	nuclear membrane
GO:0005634	IDA:MGI	C	nucleus
GO:0046930	IDA:BHF-UCL	C	pore complex
GO:0051434	IPI:UniProtKB	F	BH3 domain binding
GO:0015267	IDA:BHF-UCL	F	channel activity
GO:0016248	IDA:BHF-UCL	F	channel inhibitor activity
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0002020	IDA:UniProtKB	F	protease binding
GO:0046982	IPI:UniProtKB	F	protein heterodimerization activity
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0043565	IDA:MGI	F	sequence-specific DNA binding
GO:0031625	IPI:UniProtKB	F	ubiquitin protein ligase binding
GO:0007015	IEA:Ensembl	P	actin filament organization
GO:0006915	IDA:MGI	P	apoptotic process
GO:0007409	IEA:Ensembl	P	axonogenesis
GO:0031103	IEA:Ensembl	P	axon regeneration
GO:0001782	IEA:Ensembl	P	B cell homeostasis
GO:0002326	IEA:Ensembl	P	B cell lineage commitment
GO:0042100	IDA:MGI	P	B cell proliferation
GO:0050853	IMP:UniProtKB	P	B cell receptor signaling pathway
GO:0001662	IEA:Ensembl	P	behavioral fear response
GO:0001658	IEA:Ensembl	P	branching involved in ureteric bud morphogenesis
GO:0043375	IEA:Ensembl	P	CD8-positive, alpha-beta T cell lineage commitment
GO:0007569	IEA:Ensembl	P	cell aging
GO:0016049	IEA:Ensembl	P	cell growth
GO:0006974	IMP:UniProtKB	P	cellular response to DNA damage stimulus
GO:0042149	IEA:Ensembl	P	cellular response to glucose starvation
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0071310	IEA:Ensembl	P	cellular response to organic substance
GO:0021747	IEA:Ensembl	P	cochlear nucleus development
GO:0051607	IDA:UniProtKB	P	defense response to virus
GO:0048589	IEA:Ensembl	P	developmental growth
GO:0048546	IEA:Ensembl	P	digestive tract morphogenesis
GO:0043583	IEA:Ensembl	P	ear development
GO:0032469	TAS:UniProtKB	P	endoplasmic reticulum calcium ion homeostasis
GO:0097192	IEA:Ensembl	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0008625	IDA:MGI	P	extrinsic apoptotic signaling pathway via death domain receptors
GO:0007565	NAS:UniProtKB	P	female pregnancy
GO:0048041	IEA:Ensembl	P	focal adhesion assembly
GO:0022612	IEA:Ensembl	P	gland morphogenesis
GO:0032835	IEA:Ensembl	P	glomerulus development
GO:0031069	IEA:Ensembl	P	hair follicle morphogenesis
GO:0048873	IEA:Ensembl	P	homeostasis of number of cells within a tissue
GO:0006959	TAS:UniProtKB	P	humoral immune response
GO:0045087	TAS:Reactome	P	innate immune response
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0008630	IBA:GO_Central	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0070059	IDA:MGI	P	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0002320	IEA:Ensembl	P	lymphoid progenitor cell differentiation
GO:0008584	IEA:Ensembl	P	male gonad development
GO:0006582	IEA:Ensembl	P	melanin metabolic process
GO:0030318	IEA:Ensembl	P	melanocyte differentiation
GO:0014031	IEA:Ensembl	P	mesenchymal cell development
GO:0001656	IEA:Ensembl	P	metanephros development
GO:2000811	IMP:UniProtKB	P	negative regulation of anoikis
GO:0043066	IDA:UniProtKB	P	negative regulation of apoptotic process
GO:2001234	IMP:UniProtKB	P	negative regulation of apoptotic signaling pathway
GO:0010507	TAS:UniProtKB	P	negative regulation of autophagy
GO:0010523	IEA:Ensembl	P	negative regulation of calcium ion transport into cytosol
GO:0030308	IEA:Ensembl	P	negative regulation of cell growth
GO:0030336	IEA:Ensembl	P	negative regulation of cell migration
GO:0032848	IDA:UniProtKB	P	negative regulation of cellular pH reduction
GO:2001240	IGI:MGI	P	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2000134	IEA:Ensembl	P	negative regulation of G1/S transition of mitotic cell cycle
GO:2001243	IDA:UniProtKB	P	negative regulation of intrinsic apoptotic signaling pathway
GO:0051902	TAS:UniProtKB	P	negative regulation of mitochondrial depolarization
GO:0033033	IEA:Ensembl	P	negative regulation of myeloid cell apoptotic process
GO:0043524	IDA:MGI	P	negative regulation of neuron apoptotic process
GO:0030279	IEA:Ensembl	P	negative regulation of ossification
GO:0033689	IEA:Ensembl	P	negative regulation of osteoblast proliferation
GO:0046671	IEA:Ensembl	P	negative regulation of retinal cell programmed cell death
GO:0051402	TAS:HGNC	P	neuron apoptotic process
GO:0035872	TAS:Reactome	P	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0048599	IEA:Ensembl	P	oocyte development
GO:0035265	IEA:Ensembl	P	organ growth
GO:0001503	IEA:Ensembl	P	ossification
GO:0001541	IEA:Ensembl	P	ovarian follicle development
GO:0018105	IEA:Ensembl	P	peptidyl-serine phosphorylation
GO:0018107	IEA:Ensembl	P	peptidyl-threonine phosphorylation
GO:0048753	IEA:Ensembl	P	pigment granule organization
GO:0030890	IMP:UniProtKB	P	positive regulation of B cell proliferation
GO:0043085	IEA:Ensembl	P	positive regulation of catalytic activity
GO:0030307	IDA:MGI	P	positive regulation of cell growth
GO:2001244	TAS:Reactome	P	positive regulation of intrinsic apoptotic signaling pathway
GO:0045636	IEA:Ensembl	P	positive regulation of melanocyte differentiation
GO:0040018	IEA:Ensembl	P	positive regulation of multicellular organism growth
GO:0014042	IEA:Ensembl	P	positive regulation of neuron maturation
GO:0033138	IEA:Ensembl	P	positive regulation of peptidyl-serine phosphorylation
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0048743	IEA:Ensembl	P	positive regulation of skeletal muscle fiber development
GO:0014911	IEA:Ensembl	P	positive regulation of smooth muscle cell migration
GO:0009791	IEA:Ensembl	P	post-embryonic development
GO:0006470	IEA:Ensembl	P	protein dephosphorylation
GO:0000209	IDA:MGI	P	protein polyubiquitination
GO:0072593	IEA:Ensembl	P	reactive oxygen species metabolic process
GO:0051924	IDA:MGI	P	regulation of calcium ion transport
GO:0001952	IEA:Ensembl	P	regulation of cell-matrix adhesion
GO:0010559	IEA:Ensembl	P	regulation of glycoprotein biosynthetic process
GO:0046902	ISS:HGNC	P	regulation of mitochondrial membrane permeability
GO:0051881	ISS:HGNC	P	regulation of mitochondrial membrane potential
GO:0006808	IEA:Ensembl	P	regulation of nitrogen utilization
GO:0043497	IDA:UniProtKB	P	regulation of protein heterodimerization activity
GO:0043496	IDA:UniProtKB	P	regulation of protein homodimerization activity
GO:0031647	IEA:Ensembl	P	regulation of protein stability
GO:0022898	IDA:BHF-UCL	P	regulation of transmembrane transporter activity
GO:0045069	IEA:Ensembl	P	regulation of viral genome replication
GO:0001836	NAS:UniProtKB	P	release of cytochrome c from mitochondria
GO:0003014	IEA:Ensembl	P	renal system process
GO:0001101	IEA:Ensembl	P	response to acid chemical
GO:0034097	IDA:MGI	P	response to cytokine
GO:0042493	IMP:UniProtKB	P	response to drug
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0051384	IEA:Ensembl	P	response to glucocorticoid
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0010039	IDA:UniProtKB	P	response to iron ion
GO:0002931	IEA:Ensembl	P	response to ischemia
GO:0035094	IDA:UniProtKB	P	response to nicotine
GO:0009314	NAS:UniProtKB	P	response to radiation
GO:0009636	IDA:HGNC	P	response to toxic substance
GO:0010224	IEA:Ensembl	P	response to UV-B
GO:0016337	IEA:Ensembl	P	single organismal cell-cell adhesion
GO:0048536	IEA:Ensembl	P	spleen development
GO:0033077	IEA:Ensembl	P	T cell differentiation in thymus
GO:0043029	IEA:Ensembl	P	T cell homeostasis
GO:0048538	IEA:Ensembl	P	thymus development
GO:0055085	IDA:GOC	P	transmembrane transport

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_549	Activation of BAD and translocation to mitochondria
REACT_697	Activation of BH3-only proteins
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_6900	Immune System
REACT_75900	Inflammasomes
REACT_6802	Innate Immune System
REACT_964	Intrinsic Pathway for Apoptosis
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_268456	Programmed Cell Death
REACT_75927	The NLRP1 inflammasome