MGP Database

MGP000299

Ontology/Pathway Information

Entrez Gene ID	598
Gene Name	BCL2-like 1
Gene Symbol	BCL2L1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0097136	IDA:UniProtKB	C	Bcl-2 family protein complex
GO:0030054	IEA:UniProtKB-KW	C	cell junction
GO:0005813	IDA:UniProtKB	C	centrosome
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005829	IEA:UniProtKB-SubCell	C	cytosol
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005743	IEA:UniProtKB-SubCell	C	mitochondrial inner membrane
GO:0005759	IEA:UniProtKB-SubCell	C	mitochondrial matrix
GO:0005741	IDA:UniProtKB	C	mitochondrial outer membrane
GO:0005739	IDA:HGNC	C	mitochondrion
GO:0031965	IEA:UniProtKB-SubCell	C	nuclear membrane
GO:0005730	IDA:HPA	C	nucleolus
GO:0005634	IDA:HPA	C	nucleus
GO:0030672	IEA:UniProtKB-SubCell	C	synaptic vesicle membrane
GO:0051434	IPI:UniProtKB	F	BH3 domain binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0046982	IBA:GO_Central	F	protein heterodimerization activity
GO:0042803	IBA:GO_Central	F	protein homodimerization activity
GO:0019901	IPI:UniProtKB	F	protein kinase binding
GO:0008637	TAS:ProtInc	P	apoptotic mitochondrial changes
GO:0006915	TAS:Reactome	P	apoptotic process
GO:0071839	IEA:Ensembl	P	apoptotic process in bone marrow
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0060154	IEA:Ensembl	P	cellular process regulating host cell cycle in response to virus
GO:0071312	IEA:Ensembl	P	cellular response to alkaloid
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0071480	IEA:Ensembl	P	cellular response to gamma radiation
GO:0000910	IMP:UniProtKB	P	cytokinesis
GO:0006897	IEA:UniProtKB-KW	P	endocytosis
GO:0097192	IBA:GO_Central	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0009566	IEA:Ensembl	P	fertilization
GO:0007281	IEA:Ensembl	P	germ cell development
GO:0040007	IEA:Ensembl	P	growth
GO:0097284	IEA:Ensembl	P	hepatocyte apoptotic process
GO:0045087	TAS:Reactome	P	innate immune response
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0008630	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0008584	IEA:Ensembl	P	male gonad development
GO:0070584	IEA:Ensembl	P	mitochondrion morphogenesis
GO:0007093	IMP:UniProtKB	P	mitotic cell cycle checkpoint
GO:2000811	IMP:UniProtKB	P	negative regulation of anoikis
GO:0043066	IDA:UniProtKB	P	negative regulation of apoptotic process
GO:0010507	TAS:UniProtKB	P	negative regulation of autophagy
GO:0090005	IDA:BHF-UCL	P	negative regulation of establishment of protein localization to plasma membrane
GO:1900118	IDA:UniProtKB	P	negative regulation of execution phase of apoptosis
GO:2001240	TAS:BHF-UCL	P	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	IDA:BHF-UCL	P	negative regulation of intrinsic apoptotic signaling pathway
GO:1902230	IDA:BHF-UCL	P	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0090201	IDA:UniProtKB	P	negative regulation of release of cytochrome c from mitochondria
GO:0051402	IEA:Ensembl	P	neuron apoptotic process
GO:0035872	TAS:Reactome	P	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0001541	IEA:Ensembl	P	ovarian follicle development
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:2001244	TAS:Reactome	P	positive regulation of intrinsic apoptotic signaling pathway
GO:0046902	IDA:HGNC	P	regulation of mitochondrial membrane permeability
GO:0051881	IDA:HGNC	P	regulation of mitochondrial membrane potential
GO:0001836	IDA:HGNC	P	release of cytochrome c from mitochondria
GO:0046898	IEA:Ensembl	P	response to cycloheximide
GO:0034097	IDA:MGI	P	response to cytokine
GO:0007283	IEA:Ensembl	P	spermatogenesis
GO:0019050	IDA:MGI	P	suppression by virus of host apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_6900	Immune System
REACT_75900	Inflammasomes
REACT_6802	Innate Immune System
REACT_964	Intrinsic Pathway for Apoptosis
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_268456	Programmed Cell Death
REACT_75927	The NLRP1 inflammasome