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MGP000299

UniProt Annotations

Entry Information
Gene NameBCL2-like 1
Protein EntryB2CL1_HUMAN
UniProt IDQ07817
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Bcl-X(L); Synonyms=Bcl-xL; IsoId=Q07817-1; Sequence=Displayed; Name=Bcl-X(S); Synonyms=Bcl-xS; IsoId=Q07817-2; Sequence=VSP_000515; Name=Bcl-X(beta); IsoId=Q07817-3; Sequence=VSP_000516;
DomainThe BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
FunctionIsoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.
FunctionIsoform Bcl-X(S) promotes apoptosis.
FunctionPotent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
InteractionSelf; NbExp=2; IntAct=EBI-78035, EBI-78035; Q92934:BAD; NbExp=6; IntAct=EBI-287195, EBI-700771; Q61337:Bad (xeno); NbExp=2; IntAct=EBI-287195, EBI-400328; Q16611:BAK1; NbExp=10; IntAct=EBI-287195, EBI-519866; Q07812:BAX; NbExp=13; IntAct=EBI-287195, EBI-516580; Q9BXH1:BBC3; NbExp=7; IntAct=EBI-287195, EBI-519884; Q99ML1:Bbc3 (xeno); NbExp=3; IntAct=EBI-287195, EBI-727801; O43521:BCL2L11; NbExp=10; IntAct=EBI-287195, EBI-526406; O43521-1:BCL2L11; NbExp=2; IntAct=EBI-287195, EBI-526416; Q14457:BECN1; NbExp=4; IntAct=EBI-287195, EBI-949378; P55957:BID; NbExp=6; IntAct=EBI-287195, EBI-519672; Q13323:BIK; NbExp=3; IntAct=EBI-287195, EBI-700794; P30429:ced-4 (xeno); NbExp=3; IntAct=EBI-78035, EBI-494118; P10909-4:CLU; NbExp=6; IntAct=EBI-287195, EBI-4322678; P99999:CYCS; NbExp=2; IntAct=EBI-78035, EBI-446479; O00198:HRK; NbExp=3; IntAct=EBI-287195, EBI-701322; Q9C000:NLRP1; NbExp=9; IntAct=EBI-78035, EBI-1220518; O15304:SIVA1; NbExp=2; IntAct=EBI-78035, EBI-520756; O15304-1:SIVA1; NbExp=5; IntAct=EBI-287195, EBI-520766; Q9H2V7:SPNS1; NbExp=3; IntAct=EBI-78035, EBI-1386527; P04637:TP53; NbExp=18; IntAct=EBI-287195, EBI-366083; P02340:Tp53 (xeno); NbExp=3; IntAct=EBI-287195, EBI-474016; Q13625:TP53BP2; NbExp=4; IntAct=EBI-287195, EBI-77642; Q86Y07-1:VRK2; NbExp=2; IntAct=EBI-287195, EBI-1207633;
PtmPhosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis. {ECO:0000269|PubMed:19917720, ECO:0000269|PubMed:21840391}.
PtmProteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. {ECO:0000269|PubMed:9435230}.
SimilarityBelongs to the Bcl-2 family. {ECO:0000305}.
Subcellular LocationIsoform Bcl-X(L): Mitochondrion inner membrane {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49. {ECO:0000250}.
SubunitHomodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP/C22orf29. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase. {ECO:0000269|PubMed:10772918, ECO:0000269|PubMed:11206074, ECO:0000269|PubMed:11463391, ECO:0000269|PubMed:11714801, ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:17046835, ECO:0000269|PubMed:17337444, ECO:0000269|PubMed:21639858, ECO:0000269|PubMed:23340338, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:9675101}.
Tissue SpecificityBcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCL2L1ID129ch20q11.html";
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