MGP Database

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MGP000322

Ontology/Pathway Information

Entrez Gene ID652
Gene Namebone morphogenetic protein 4
Gene Symbol BMP4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005576 ISS:UniProtKBCextracellular region
GO:0005615 ISS:UniProtKBCextracellular space
GO:0005578 IEA:UniProtKB-SubCellCproteinaceous extracellular matrix
GO:0070700 IDA:MGIFBMP receptor binding
GO:0042056 IDA:UniProtKBFchemoattractant activity
GO:0005125 IDA:MGIFcytokine activity
GO:0008201 IEA:EnsemblFheparin binding
GO:0000186 IDA:UniProtKBPactivation of MAPKK activity
GO:0009948 IEA:EnsemblPanterior/posterior axis specification
GO:0002043 IDA:BHF-UCLPblood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0030509 IDA:BHF-UCLPBMP signaling pathway
GO:0003130 IMP:BHF-UCLPBMP signaling pathway involved in heart induction
GO:0071893 IDA:UniProtKBPBMP signaling pathway involved in nephric duct formation
GO:0061151 ISS:UniProtKBPBMP signaling pathway involved in renal system segmentation
GO:0061149 ISS:UniProtKBPBMP signaling pathway involved in ureter morphogenesis
GO:0060442 IEA:EnsemblPbranching involved in prostate gland morphogenesis
GO:0001658 IDA:UniProtKBPbranching involved in ureteric bud morphogenesis
GO:0048754 IDA:UniProtKBPbranching morphogenesis of an epithelial tube
GO:0060433 IDA:MGIPbronchus development
GO:0060503 IDA:MGIPbud dilation involved in lung branching
GO:0060449 IEA:EnsemblPbud elongation involved in lung branching
GO:0003279 TAS:BHF-UCLPcardiac septum development
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0002062 ISS:UniProtKBPchondrocyte differentiation
GO:0060197 IEA:EnsemblPcloacal septation
GO:0007182 IDA:UniProtKBPcommon-partner SMAD protein phosphorylation
GO:0060363 IEA:EnsemblPcranial suture morphogenesis
GO:0035993 ISS:UniProtKBPdeltoid tuberosity development
GO:0021904 IEA:EnsemblPdorsal/ventral neural tube patterning
GO:0048701 IEA:EnsemblPembryonic cranial skeleton morphogenesis
GO:0042733 IEA:EnsemblPembryonic digit morphogenesis
GO:0035116 IEA:EnsemblPembryonic hindlimb morphogenesis
GO:0060272 IEA:EnsemblPembryonic skeletal joint morphogenesis
GO:0003197 TAS:BHF-UCLPendocardial cushion development
GO:0001958 ISS:UniProtKBPendochondral ossification
GO:0060502 IDA:MGIPepithelial cell proliferation involved in lung morphogenesis
GO:0060684 IEA:EnsemblPepithelial-mesenchymal cell signaling
GO:0060441 IDA:MGIPepithelial tube branching involved in lung morphogenesis
GO:0030218 IEA:EnsemblPerythrocyte differentiation
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0007281 IEA:EnsemblPgerm cell development
GO:0072104 ISS:UniProtKBPglomerular capillary formation
GO:0072015 IEA:EnsemblPglomerular visceral epithelial cell development
GO:0002244 IDA:UniProtKBPhematopoietic progenitor cell differentiation
GO:0060113 IEA:EnsemblPinner ear receptor cell differentiation
GO:0048392 IDA:UniProtKBPintermediate mesodermal cell differentiation
GO:0001822 IMP:UniProtKBPkidney development
GO:0060235 IEA:EnsemblPlens induction in camera-type eye
GO:0048286 IDA:MGIPlung alveolus development
GO:0060425 IDA:MGIPlung morphogenesis
GO:0002320 IMP:BHF-UCLPlymphoid progenitor cell differentiation
GO:0030225 IDA:DFLATPmacrophage differentiation
GO:0060592 IEA:EnsemblPmammary gland formation
GO:0072161 IEA:EnsemblPmesenchymal cell differentiation involved in kidney development
GO:0072198 IEA:EnsemblPmesenchymal cell proliferation involved in ureter development
GO:0072138 IEA:EnsemblPmesenchymal cell proliferation involved in ureteric bud development
GO:0003337 IDA:UniProtKBPmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007500 IEA:EnsemblPmesodermal cell fate determination
GO:0001823 IEP:UniProtKBPmesonephros development
GO:0072205 ISS:UniProtKBPmetanephric collecting duct development
GO:0030224 IDA:DFLATPmonocyte differentiation
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0072097 IDA:UniProtKBPnegative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0090191 IDA:UniProtKBPnegative regulation of branching involved in ureteric bud morphogenesis
GO:0045786 IDA:HGNCPnegative regulation of cell cycle
GO:0060548 IDA:UniProtKBPnegative regulation of cell death
GO:0008285 IDA:MGIPnegative regulation of cell proliferation
GO:2000137 IMP:BHF-UCLPnegative regulation of cell proliferation involved in heart morphogenesis
GO:0032331 IEA:EnsemblPnegative regulation of chondrocyte differentiation
GO:0050680 IEA:EnsemblPnegative regulation of epithelial cell proliferation
GO:0072125 IDA:UniProtKBPnegative regulation of glomerular mesangial cell proliferation
GO:0090194 IDA:UniProtKBPnegative regulation of glomerulus development
GO:0033088 IMP:BHF-UCLPnegative regulation of immature T cell proliferation in thymus
GO:0043407 IDA:UniProtKBPnegative regulation of MAP kinase activity
GO:0072200 IDA:UniProtKBPnegative regulation of mesenchymal cell proliferation involved in ureter development
GO:2000007 IDA:UniProtKBPnegative regulation of metanephric comma-shaped body morphogenesis
GO:2000005 IDA:UniProtKBPnegative regulation of metanephric S-shaped body morphogenesis
GO:0045839 IDA:UniProtKBPnegative regulation of mitosis
GO:0045662 IDA:MGIPnegative regulation of myoblast differentiation
GO:0042326 IDA:UniProtKBPnegative regulation of phosphorylation
GO:0060686 IEA:EnsemblPnegative regulation of prostatic bud formation
GO:0045843 IDA:MGIPnegative regulation of striated muscle tissue development
GO:0033085 IMP:BHF-UCLPnegative regulation of T cell differentiation in thymus
GO:0070244 IMP:BHF-UCLPnegative regulation of thymocyte apoptotic process
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:MGIPnegative regulation of transcription from RNA polymerase II promoter
GO:0001843 IEA:EnsemblPneural tube closure
GO:0048663 IEA:EnsemblPneuron fate commitment
GO:0042476 IGI:UniProtKBPodontogenesis
GO:0042475 IEA:EnsemblPodontogenesis of dentin-containing tooth
GO:0001649 IDA:BHF-UCLPosteoblast differentiation
GO:0021983 IEA:EnsemblPpituitary gland development
GO:0050918 IDA:GOCPpositive chemotaxis
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0030513 ISS:UniProtKBPpositive regulation of BMP signaling pathway
GO:0030501 IDA:UniProtKBPpositive regulation of bone mineralization
GO:0061047 ISS:UniProtKBPpositive regulation of branching involved in lung morphogenesis
GO:0055020 IMP:BHF-UCLPpositive regulation of cardiac muscle fiber development
GO:0061036 IDA:MGIPpositive regulation of cartilage development
GO:0010942 IDA:MGIPpositive regulation of cell death
GO:0032967 IDA:BHF-UCLPpositive regulation of collagen biosynthetic process
GO:2000105 IDA:BHF-UCLPpositive regulation of DNA-dependent DNA replication
GO:0045603 IEA:EnsemblPpositive regulation of endothelial cell differentiation
GO:0010595 IDA:UniProtKBPpositive regulation of endothelial cell migration
GO:0001938 IDA:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0045606 IDA:UniProtKBPpositive regulation of epidermal cell differentiation
GO:0050679 IDA:BHF-UCLPpositive regulation of epithelial cell proliferation
GO:0070374 IEA:EnsemblPpositive regulation of ERK1 and ERK2 cascade
GO:0090184 IDA:UniProtKBPpositive regulation of kidney development
GO:0045666 IEA:EnsemblPpositive regulation of neuron differentiation
GO:0045778 IDA:MGIPpositive regulation of ossification
GO:0045669 IDA:BHF-UCLPpositive regulation of osteoblast differentiation
GO:0010862 IDA:UniProtKBPpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0032092 IDA:MGIPpositive regulation of protein binding
GO:0001934 IDA:MGIPpositive regulation of protein phosphorylation
GO:0060391 IDA:BHF-UCLPpositive regulation of SMAD protein import into nucleus
GO:0048661 IDA:UniProtKBPpositive regulation of smooth muscle cell proliferation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0009791 IDA:MGIPpost-embryonic development
GO:0034504 IDA:UniProtKBPprotein localization to nucleus
GO:0061155 IDA:UniProtKBPpulmonary artery endothelial tube morphogenesis
GO:0060687 IEA:EnsemblPregulation of branching involved in prostate gland morphogenesis
GO:0010453 IDA:UniProtKBPregulation of cell fate commitment
GO:0042487 IEA:EnsemblPregulation of odontogenesis of dentin-containing tooth
GO:0060393 IDA:BHF-UCLPregulation of pathway-restricted SMAD protein phosphorylation
GO:0042306 IDA:MGIPregulation of protein import into nucleus
GO:0051150 IEA:EnsemblPregulation of smooth muscle cell differentiation
GO:0072001 IEP:UniProtKBPrenal system development
GO:0003014 IEA:EnsemblPrenal system process
GO:0003139 IMP:BHF-UCLPsecondary heart field specification
GO:0060395 IDA:UniProtKBPSMAD protein signal transduction
GO:0007224 IEP:UniProtKBPsmoothened signaling pathway
GO:0048745 ISS:UniProtKBPsmooth muscle tissue development
GO:0010159 IEA:EnsemblPspecification of organ position
GO:0072101 IDA:UniProtKBPspecification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0043401 IMP:UniProtKBPsteroid hormone mediated signaling pathway
GO:0021537 IDA:MGIPtelencephalon development
GO:0021978 IEA:EnsemblPtelencephalon regionalization
GO:0035990 ISS:UniProtKBPtendon cell differentiation
GO:0060438 IDA:MGIPtrachea development
GO:0060440 IEA:EnsemblPtrachea formation
GO:0003323 IDA:BHF-UCLPtype B pancreatic cell development
GO:0072192 ISS:UniProtKBPureter epithelial cell differentiation
GO:0001657 IDA:MGIPureteric bud development
GO:0072193 ISS:UniProtKBPureter smooth muscle cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_150366Elastic fibre formation
REACT_118779Extracellular matrix organization
REACT_150331Molecules associated with elastic fibres
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