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MGP000338

Record overview

MGPD IDMGP000338
Gene ID683
SpeciesHomo sapiens (Human)
Gene Namebone marrow stromal cell antigen 1
Gene Symbol BST1
SynonymsCD157;
Alternate namesADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; BST-1; cADPr hydrolase 2; NAD(+) nucleosidase; ADP-ribosyl cyclase 2; bone marrow stromal antigen 1; cyclic ADP-ribose hydrolase 2;
Chromosome4
Map Location4p15
EC Number3.2.2.6
SummaryBone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BST1

Proteins

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor
Refseq ID:NP_004325
Protein GI:168229159
UniProt ID:Q10588
mRNA ID:NM_004334
Length:318
RefSeq Status:
MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHS
IPRDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAY
PIKGFFADYEIPNLQKEKITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKAPSLYTEQ
RAGLIIPLFLVLASRTQL
 
sig_peptide: 1..28
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q10588.2)
calculated_mol_wt: 2892
peptide sequence: 
MAAQGCAASRLLQLLLQLLLLLLLLAAG

mat_peptide: 29..293
product: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q10588.2)
calculated_mol_wt: 30068
peptide sequence: 
GARARWRGEGTSAHLRDIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENSHLLVNSFADNTRRFMP
LSDVLYGRVADFLSWCRQKNDSGLDYQSCPTSEDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEKITRIEIWVMH
EIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHSTHPDCALKSAAAATQRKA
 
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