MGP Database

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MGP000377

UniProt Annotations

Entry Information
Gene Namecarbonic anhydrase IX
Protein EntryCAH9_HUMAN
UniProt IDQ16790
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:19805286};
Catalytic ActivityH(2)CO(3) = CO(2) + H(2)O.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme RegulationInhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.
FunctionReversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. {ECO:0000269|PubMed:18703501}.
InductionBy hypoxia. {ECO:0000269|PubMed:18703501}.
PtmAsn-346 bears high-mannose type glycan structures.
SimilarityBelongs to the alpha-carbonic anhydrase family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
SubunitForms oligomers linked by disulfide bonds. {ECO:0000269|PubMed:18041760, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19805286}.
Tissue SpecificityExpressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
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