MGP Database

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MGP000399

Ontology/Pathway Information

Entrez Gene ID811
Gene Namecalreticulin
Gene Symbol CALR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0001669 IEA:EnsemblCacrosomal vesicle
GO:0009986 TAS:BHF-UCLCcell surface
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0071682 TAS:ReactomeCendocytic vesicle lumen
GO:0005783 TAS:UniProtKBCendoplasmic reticulum
GO:0005788 IDA:UniProtKBCendoplasmic reticulum lumen
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005794 IEA:EnsemblCGolgi apparatus
GO:0071556 TAS:ReactomeCintegral component of lumenal side of endoplasmic reticulum membrane
GO:0005622 TAS:UniProtKBCintracellular
GO:0016020 IDA:UniProtKBCmembrane
GO:0042824 ISS:BHF-UCLCMHC class I peptide loading complex
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:BHF-UCLCperinuclear region of cytoplasm
GO:0005844 ISS:BHF-UCLCpolysome
GO:0005578 IEA:UniProtKB-SubCellCproteinaceous extracellular matrix
GO:0033018 IEA:UniProtKB-SubCellCsarcoplasmic reticulum lumen
GO:0005790 IEA:EnsemblCsmooth endoplasmic reticulum
GO:0050681 IDA:BHF-UCLFandrogen receptor binding
GO:0005509 ISS:UniProtKBFcalcium ion binding
GO:0030246 TAS:BHF-UCLFcarbohydrate binding
GO:0051087 TAS:BHF-UCLFchaperone binding
GO:0001849 TAS:BHF-UCLFcomplement component C1q binding
GO:0003677 NAS:UniProtKBFDNA binding
GO:0001948 IPI:UniProtKBFglycoprotein binding
GO:0042562 IEA:EnsemblFhormone binding
GO:0005178 IPI:BHF-UCLFintegrin binding
GO:0005506 IEA:EnsemblFiron ion binding
GO:0003729 IDA:BHF-UCLFmRNA binding
GO:0042277 IEA:EnsemblFpeptide binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0044183 TAS:BHF-UCLFprotein binding involved in protein folding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0051082 TAS:BHF-UCLFunfolded protein binding
GO:0008270 TAS:BHF-UCLFzinc ion binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0042590 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479 TAS:ReactomePantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474 TAS:ReactomePantigen processing and presentation of peptide antigen via MHC class I
GO:0055007 IEA:EnsemblPcardiac muscle cell differentiation
GO:0007050 IGI:BHF-UCLPcell cycle arrest
GO:0006874 TAS:UniProtKBPcellular calcium ion homeostasis
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0071285 IEA:EnsemblPcellular response to lithium ion
GO:0090398 IGI:BHF-UCLPcellular senescence
GO:0061077 IEA:EnsemblPchaperone-mediated protein folding
GO:0030866 IEA:EnsemblPcortical actin cytoskeleton organization
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0042921 TAS:BHF-UCLPglucocorticoid receptor signaling pathway
GO:0033144 IDA:BHF-UCLPnegative regulation of intracellular steroid hormone receptor signaling pathway
GO:0045665 IDA:BHF-UCLPnegative regulation of neuron differentiation
GO:0048387 IDA:BHF-UCLPnegative regulation of retinoic acid receptor signaling pathway
GO:0045892 IDA:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0017148 ISS:BHF-UCLPnegative regulation of translation
GO:0002502 ISS:BHF-UCLPpeptide antigen assembly with MHC class I protein complex
GO:0045787 IGI:BHF-UCLPpositive regulation of cell cycle
GO:0008284 IGI:BHF-UCLPpositive regulation of cell proliferation
GO:2000510 IMP:UniProtKBPpositive regulation of dendritic cell chemotaxis
GO:0045740 IGI:BHF-UCLPpositive regulation of DNA replication
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0050766 ISS:BHF-UCLPpositive regulation of phagocytosis
GO:1900026 IMP:UniProtKBPpositive regulation of substrate adhesion-dependent cell spreading
GO:0043687 TAS:ReactomePpost-translational protein modification
GO:0006611 IDA:UniProtKBPprotein export from nucleus
GO:0006457 TAS:BHF-UCLPprotein folding
GO:0034504 IDA:UniProtKBPprotein localization to nucleus
GO:0022417 TAS:BHF-UCLPprotein maturation by protein folding
GO:0018279 TAS:ReactomePprotein N-linked glycosylation via asparagine
GO:0050821 ISS:UniProtKBPprotein stabilization
GO:0042981 TAS:UniProtKBPregulation of apoptotic process
GO:0040020 IEA:EnsemblPregulation of meiosis
GO:0006355 TAS:ProtIncPregulation of transcription, DNA-templated
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0051208 TAS:BHF-UCLPsequestering of calcium ion
GO:0007283 IEA:EnsemblPspermatogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_75795Antigen Presentation: Folding, assembly and peptide loading of class I MHC
REACT_111119Antigen processing-Cross presentation
REACT_22426Asparagine N-linked glycosylation
REACT_6277Assembly of Viral Components at the Budding Site
REACT_18423ATF6-alpha activates chaperone genes
REACT_18348ATF6-alpha activates chaperones
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_23810Calnexin/calreticulin cycle
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_111178ER-Phagosome pathway
REACT_6900Immune System
REACT_6167Influenza Infection
REACT_6145Influenza Life Cycle
REACT_17015Metabolism of proteins
REACT_23878N-glycan trimming in the ER and Calnexin/Calreticulin cycle
REACT_22161Post-translational protein modification
REACT_163699Scavenging by Class A Receptors
REACT_163813Scavenging by Class F Receptors
REACT_18356Unfolded Protein Response (UPR)
REACT_6270Virus Assembly and Release
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