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MGP000399

UniProt Annotations

Entry Information
Gene Namecalreticulin
Protein EntryCALR_HUMAN
UniProt IDP27797
SpeciesHuman
Comments
Comment typeDescription
CautionWas originally thought to be the 52 kDa Ro autoantigen. {ECO:0000305|PubMed:2332496}.
DomainAssociates with PDIA3 through the tip of the extended arm formed by the P-domain.
DomainCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
DomainThe interaction with glycans occurs through a binding site in the globular lectin domain.
DomainThe zinc binding sites are localized to the N-domain.
FunctionCalcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). {ECO:0000250}.
InteractionP05067:APP; NbExp=2; IntAct=EBI-1049597, EBI-77613; O95166:GABARAP; NbExp=4; IntAct=EBI-1049597, EBI-712001; P04792:HSPB1; NbExp=2; IntAct=EBI-1049597, EBI-352682; Q03518:TAP1; NbExp=2; IntAct=EBI-1049597, EBI-747259;
Mass SpectrometryMass=46879; Method=MALDI; Range=18-417; Evidence={ECO:0000269|PubMed:11149926};
SimilarityBelongs to the calreticulin family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
SubunitMonomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and C9orf9 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Interacts with PPIB. {ECO:0000250|UniProtKB:P14211, ECO:0000250|UniProtKB:P18418, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:19154346, ECO:0000269|PubMed:20801878, ECO:0000269|PubMed:21423620, ECO:0000269|PubMed:8666824}.
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Calreticulin; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_405";
Web ResourceName=Wikipedia; Note=Calreticulin entry; URL="http://en.wikipedia.org/wiki/Calreticulin";
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