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MGP000406

UniProt Annotations

Entry Information
Gene Namecalnexin
Protein EntryCALX_HUMAN
UniProt IDP27824
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P27824-1; Sequence=Displayed; Name=2; IsoId=P27824-2; Sequence=VSP_055516; Note=No experimental confirmation available.; Name=3; IsoId=P27824-3; Sequence=VSP_055515; Note=No experimental confirmation available.;
FunctionCalcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
InteractionP11607:ATP2A2 (xeno); NbExp=2; IntAct=EBI-355947, EBI-8004986; P13569:CFTR; NbExp=3; IntAct=EBI-355947, EBI-349854; Q92597:NDRG1; NbExp=2; IntAct=EBI-355947, EBI-716486; P41143:OPRD1; NbExp=2; IntAct=EBI-355947, EBI-2624456; P30050:RPL12; NbExp=3; IntAct=EBI-355947, EBI-352743; P61619:SEC61A1; NbExp=3; IntAct=EBI-355947, EBI-358919; P43307:SSR1; NbExp=5; IntAct=EBI-355947, EBI-714168;
PtmPalmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. {ECO:0000269|PubMed:22314232}.
PtmPhosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity). {ECO:0000250}.
SimilarityBelongs to the calreticulin family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes to the perinuclear rough ER.
SubunitInteracts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP. Interacts with PPIB. {ECO:0000250, ECO:0000269|PubMed:16361248, ECO:0000269|PubMed:20801878, ECO:0000269|PubMed:22016385, ECO:0000269|PubMed:22314232, ECO:0000269|PubMed:23826168}.
Web ResourceName=Wikipedia; Note=Calnexin entry; URL="http://en.wikipedia.org/wiki/Calnexin";
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