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MGP000407

Record overview

MGPD IDMGP000407
Gene ID823
SpeciesHomo sapiens (Human)
Gene Namecalpain 1, (mu/I) large subunit
Gene Symbol CAPN1
SynonymsCANP; muCL; CANP1; CANPL1; muCANP;
Alternate namescalpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein;
Chromosome11
Map Location11q13
EC Number3.4.22.52
SummaryThe calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for CAPN1

Proteins

calpain-1 catalytic subunit
Refseq ID:NP_005177
Protein GI:12408656
UniProt ID:P07384
mRNA ID:NM_005186
Length:714
RefSeq Status:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVD
GATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNG
SYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIR
LDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPST
FEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVV
TFDLFKWLQLTMFA
 
calpain-1 catalytic subunit
Refseq ID:NP_001185797
Protein GI:311893363
UniProt ID:P07384
mRNA ID:NM_001198868
Length:714
RefSeq Status:
Protein sequence is identical to GI:12408656 (mRNA isoform)
 
calpain-1 catalytic subunit
Refseq ID:NP_001185798
Protein GI:311893365
UniProt ID:P07384
mRNA ID:NM_001198869
Length:714
RefSeq Status:
Protein sequence is identical to GI:12408656 (mRNA isoform)
 
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