MGP Database

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MGP000407

UniProt Annotations

Entry Information
Gene Namecalpain 1, (mu/I) large subunit
Protein EntryCAN1_HUMAN
UniProt IDP07384
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityBroad endopeptidase specificity.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions.;
Enzyme RegulationActivated by micromolar concentrations of calcium and inhibited by calpastatin.
FunctionCalcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
InteractionP15311:EZR; NbExp=2; IntAct=EBI-1542113, EBI-1056902; P18031:PTPN1; NbExp=4; IntAct=EBI-1542113, EBI-968788; P40763:STAT3; NbExp=2; IntAct=EBI-1542113, EBI-518675;
PtmUndergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
SimilarityBelongs to the peptidase C2 family. {ECO:0000305}.
SimilarityContains 1 calpain catalytic domain. {ECO:0000255|PROSITE-ProRule:PRU00239}.
SimilarityContains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding.
SubunitForms a heterodimer with a small (regulatory) subunit (CAPNS1).
Tissue SpecificityUbiquitous.
Web ResourceName=CaBP; Note=Calpain; URL="http://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html";
Web ResourceName=Calpains homepage; URL="http://ag.arizona.edu/calpains/";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/capn1/";
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