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MGP000408

Record overview

MGPD IDMGP000408
Gene ID826
SpeciesHomo sapiens (Human)
Gene Namecalpain, small subunit 1
Gene Symbol CAPNS1
SynonymsCANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4;
Alternate namescalpain small subunit 1; CANP small subunit; calpain regulatory subunit; calpain, small polypeptide; calpain 4, small subunit (30K); calcium-dependent protease, small subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit;
Chromosome19
Map Location19q13.12
SummaryThis gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for CAPNS1

Proteins

calpain small subunit 1 isoform 1
Refseq ID:NP_001740
Protein GI:4502565
UniProt ID:P04632
mRNA ID:NM_001749
Length:268
RefSeq Status:
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQ
FRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEA
AGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
 
calpain small subunit 1 isoform 1
Refseq ID:NP_001289561
Protein GI:701461513
UniProt ID:P04632
mRNA ID:NM_001302632
Length:268
RefSeq Status:
Protein sequence is identical to GI:4502565 (mRNA isoform)
 
calpain small subunit 1 isoform 1
Refseq ID:NP_001003962
Protein GI:51599151
UniProt ID:P04632
mRNA ID:NM_001003962
Length:268
RefSeq Status:
Protein sequence is identical to GI:4502565 (mRNA isoform)
 
calpain small subunit 1 isoform 2
Refseq ID:NP_001289562
Protein GI:701461515
UniProt ID:P04632
mRNA ID:NM_001302633
Length:156
RefSeq Status:
MEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNM
IIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
 
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