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MGP000408

UniProt Annotations

Entry Information
Gene Namecalpain, small subunit 1
Protein EntryCPNS1_HUMAN
UniProt IDP04632
SpeciesHuman
Comments
Comment typeDescription
DomainEF-hand domains are paired. EF-hand 1 is paired with EF- hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF- hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.
DomainThe contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer. {ECO:0000250}.
FunctionRegulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
InteractionP17655:CAPN2; NbExp=3; IntAct=EBI-711828, EBI-1028956; P20936:RASA1; NbExp=3; IntAct=EBI-711828, EBI-1026476;
SimilarityContains 5 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
SubunitHomodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity). {ECO:0000250}.
Web ResourceName=CaBP; Note=Calpain; URL="http://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html";
Web ResourceName=Calpains homepage; URL="http://ag.arizona.edu/calpains/";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/capns1/";
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