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MGP000411

Record overview

MGPD IDMGP000411
Gene ID832
SpeciesHomo sapiens (Human)
Gene Namecapping protein (actin filament) muscle Z-line, beta
Gene Symbol CAPZB
SynonymsCAPB; CAPZ; CAPPB;
Alternate namesF-actin-capping protein subunit beta; capZ beta;
Chromosome1
Map Location1p36.1
SummaryThis gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
OrthologsView orthologs and multiple alignments for CAPZB

Proteins

F-actin-capping protein subunit beta isoform 1
Refseq ID:NP_004921
Protein GI:4826659
UniProt ID:P47756
mRNA ID:NM_004930
Length:272
RefSeq Status:
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKD
ETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
 
F-actin-capping protein subunit beta isoform 2
Refseq ID:NP_001193469
Protein GI:330864679
UniProt ID:P47756
mRNA ID:NM_001206540
Length:277
RefSeq Status:
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKD
ETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRELSQVLTQRQIYIQPDN
 
F-actin-capping protein subunit beta isoform 3
Refseq ID:NP_001193470
Protein GI:330864681
UniProt ID:B1AK85
mRNA ID:NM_001206541
Length:260
RefSeq Status:
MPRQFQDTGFSRPGLGQPRRCDPEPRKSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSP
WSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVM
LWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEVCADFCRQIKTRSSEE
 
F-actin-capping protein subunit beta isoform 4
Refseq ID:NP_001269091
Protein GI:531990816
UniProt ID:P47756
mRNA ID:NM_001282162
Length:301
RefSeq Status:
MHPSRRSLPFPLNCQLARVGTADYGSPSDQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSY
RSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQ
C
 
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