MGP Database

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MGP000411

UniProt Annotations

Entry Information
Gene Namecapping protein (actin filament) muscle Z-line, beta
Protein EntryCAPZB_HUMAN
UniProt IDP47756
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P47756-1; Sequence=Displayed; Name=2; IsoId=P47756-2; Sequence=VSP_000767; Name=3; IsoId=P47756-3; Sequence=Not described;
FunctionF-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.
SimilarityBelongs to the F-actin-capping protein beta subunit family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}.
SubunitHeterodimer of an alpha and a beta subunit. Interacts with ARHGAP17 and RCSD1/CAPZIP. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. {ECO:0000269|PubMed:15850461, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:19922875}.
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