MGP Database

MGP000413

Record overview

MGPD ID	MGP000413
Gene ID	834
Species	Homo sapiens (Human)
Gene Name	caspase 1, apoptosis-related cysteine peptidase
Gene Symbol	CASP1
Synonyms	ICE; P45; IL1BC;
Alternate names	caspase-1; CASP1 nirs variant 1; IL-1 beta-converting enzyme; IL1B-convertase; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); interleukin 1, beta, convertase; interleukin 1-B converting enzyme;
Chromosome	11
Map Location	11q23
EC Number	3.4.22.36
Summary	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Orthologs	View orthologs and multiple alignments for CASP1

Proteins

caspase-1 isoform alpha precursor

Refseq ID:	NP_150634
Protein GI:	15431328
UniProt ID:	P29466
mRNA ID:	NM_033292
Length:	404
RefSeq Status:

MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLN
MQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV
DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYL
FPGH

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform alpha precursor

Refseq ID:	NP_001244047
Protein GI:	380254457
UniProt ID:	P29466
mRNA ID:	NM_001257118
Length:	404
RefSeq Status:

Protein sequence is identical to GI:15431328 (mRNA isoform)

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 99..276
product: caspase-1 isoform beta p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 296..383
product: caspase-1 isoform beta p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform beta precursor

Refseq ID:	NP_001244048
Protein GI:	380254459
UniProt ID:	P29466
mRNA ID:	NM_001257119
Length:	383
RefSeq Status:

`MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNP AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHR PEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH`

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 99..276
product: caspase-1 isoform beta p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 296..383
product: caspase-1 isoform beta p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform beta precursor

Refseq ID:	NP_001214
Protein GI:	4502573
UniProt ID:	P29466
mRNA ID:	NM_001223
Length:	383
RefSeq Status:

Protein sequence is identical to GI:380254459 (mRNA isoform)

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 99..276
product: caspase-1 isoform beta p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 296..383
product: caspase-1 isoform beta p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 99..276
product: caspase-1 isoform beta p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 296..383
product: caspase-1 isoform beta p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform delta

Refseq ID:	NP_150636
Protein GI:	15431332
UniProt ID:	P29466
mRNA ID:	NM_033294
Length:	263
RefSeq Status:

`MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL QNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDNVSWR HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH`

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform epsilon

Refseq ID:	NP_150637
Protein GI:	15431334
UniProt ID:	P29466
mRNA ID:	NM_033295
Length:	88
RefSeq Status:

`MADKVLKEKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH`

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

mat_peptide: 120..297
product: caspase-1 isoform alpha p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 317..404
product: caspase-1 isoform alpha p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH

caspase-1 isoform gamma

Refseq ID:	NP_150635
Protein GI:	15431330
UniProt ID:	P29466
mRNA ID:	NM_033293
Length:	311
RefSeq Status:

`MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL QNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVV WFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT LTRCFYLFPGH`

mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD

mat_peptide: 224..311
product: caspase-1 isoform gamma p10 subunit
calculated_mol_wt: 10244
peptide sequence: 
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH