MGP Database

MGP000413

Record overview

MGPD IDMGP000413
Gene ID834
SpeciesHomo sapiens (Human)
Gene Namecaspase 1, apoptosis-related cysteine peptidase
Gene Symbol CASP1
SynonymsICE; P45; IL1BC;
Alternate namescaspase-1; CASP1 nirs variant 1; IL-1 beta-converting enzyme; IL1B-convertase; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); interleukin 1, beta, convertase; interleukin 1-B converting enzyme;
Chromosome11
Map Location11q23
EC Number3.4.22.36
SummaryThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for CASP1

Proteins

caspase-1 isoform alpha precursor
Refseq ID:NP_150634
Protein GI:15431328
UniProt ID:P29466
mRNA ID:NM_033292
Length:404
RefSeq Status:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLN
MQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV
DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYL
FPGH
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform alpha precursor
Refseq ID:NP_001244047
Protein GI:380254457
UniProt ID:P29466
mRNA ID:NM_001257118
Length:404
RefSeq Status:
Protein sequence is identical to GI:15431328 (mRNA isoform)
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 99..276 product: caspase-1 isoform beta p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 296..383 product: caspase-1 isoform beta p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform beta precursor
Refseq ID:NP_001244048
Protein GI:380254459
UniProt ID:P29466
mRNA ID:NM_001257119
Length:383
RefSeq Status:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNP
AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHR
PEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA
HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 99..276 product: caspase-1 isoform beta p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 296..383 product: caspase-1 isoform beta p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform beta precursor
Refseq ID:NP_001214
Protein GI:4502573
UniProt ID:P29466
mRNA ID:NM_001223
Length:383
RefSeq Status:
Protein sequence is identical to GI:380254459 (mRNA isoform)
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 99..276 product: caspase-1 isoform beta p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 296..383 product: caspase-1 isoform beta p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 99..276 product: caspase-1 isoform beta p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 296..383 product: caspase-1 isoform beta p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform delta
Refseq ID:NP_150636
Protein GI:15431332
UniProt ID:P29466
mRNA ID:NM_033294
Length:263
RefSeq Status:
MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL
QNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDNVSWR
HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform epsilon
Refseq ID:NP_150637
Protein GI:15431334
UniProt ID:P29466
mRNA ID:NM_033295
Length:88
RefSeq Status:
MADKVLKEKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH mat_peptide: 120..297 product: caspase-1 isoform alpha p20 subunit calculated_mol_wt: 19844 peptide sequence: NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 317..404 product: caspase-1 isoform alpha p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
caspase-1 isoform gamma
Refseq ID:NP_150635
Protein GI:15431330
UniProt ID:P29466
mRNA ID:NM_033293
Length:311
RefSeq Status:
MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLL
QNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVV
WFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVT
LTRCFYLFPGH
 
mat_peptide: 27..204
product: caspase-1 isoform gamm p20 subunit
calculated_mol_wt: 19844
peptide sequence: 
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKD mat_peptide: 224..311 product: caspase-1 isoform gamma p10 subunit calculated_mol_wt: 10244 peptide sequence: AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
 
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