MGP Database

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MGP000413

Ontology/Pathway Information

Entrez Gene ID834
Gene Namecaspase 1, apoptosis-related cysteine peptidase
Gene Symbol CASP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097169 IDA:UniProtKBCAIM2 inflammasome complex
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005576 IEA:EnsemblCextracellular region
GO:0072557 ISS:UniProtKBCIPAF inflammasome complex
GO:0072558 IDA:UniProtKBCNLRP1 inflammasome complex
GO:0072559 IDA:UniProtKBCNLRP3 inflammasome complex
GO:0008656 TAS:ProtIncFcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0004197 IBA:GO_CentralFcysteine-type endopeptidase activity
GO:0004175 IDA:ParkinsonsUK-UCLFendopeptidase activity
GO:0006919 TAS:GOCPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915 TAS:ProtIncPapoptotic process
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071310 IDA:MGIPcellular response to organic substance
GO:0097194 IBA:GO_CentralPexecution phase of apoptosis
GO:0045087 TAS:ReactomePinnate immune response
GO:0032611 IEA:EnsemblPinterleukin-1 beta production
GO:0060081 IEA:EnsemblPmembrane hyperpolarization
GO:0051882 IEA:EnsemblPmitochondrial depolarization
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050717 IEA:EnsemblPpositive regulation of interleukin-1 alpha secretion
GO:0050718 IEA:EnsemblPpositive regulation of interleukin-1 beta secretion
GO:0097300 IEA:EnsemblPprogrammed necrotic cell death
GO:0006508 IDA:UniProtKBPproteolysis
GO:0070269 IEA:EnsemblPpyroptosis
GO:0050727 IBA:GO_CentralPregulation of inflammatory response
GO:0033198 IEA:EnsemblPresponse to ATP
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0007165 TAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75790Cytokine Signaling in Immune system
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_23950Interleukin-1 processing
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_22232Signaling by Interleukins
REACT_75777The AIM2 inflammasome
REACT_75892The IPAF inflammasome
REACT_75808The NLRP3 inflammasome
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