MGP Database

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MGP000418

Ontology/Pathway Information

Entrez Gene ID840
Gene Namecaspase 7, apoptosis-related cysteine peptidase
Gene Symbol CASP7
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0004190 IEA:EnsemblFaspartic-type endopeptidase activity
GO:0004197 IBA:GO_CentralFcysteine-type endopeptidase activity
GO:0097153 IEA:EnsemblFcysteine-type endopeptidase activity involved in apoptotic process
GO:0008234 TAS:ProtIncFcysteine-type peptidase activity
GO:0008635 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568 IEA:EnsemblPaging
GO:0006915 TAS:ReactomePapoptotic process
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0097194 IBA:GO_CentralPexecution phase of apoptosis
GO:0007507 IEA:EnsemblPheart development
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0006508 IDA:UniProtKBPproteolysis
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0009411 IEA:EnsemblPresponse to UV
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_607Activation of caspases through apoptosome-mediated cleavage
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_963Apoptotic factor-mediated response
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_831Cytochrome c-mediated apoptotic response
REACT_964Intrinsic Pathway for Apoptosis
REACT_268456Programmed Cell Death
REACT_2190SMAC binds to IAPs
REACT_666SMAC-mediated apoptotic response
REACT_1767SMAC-mediated dissociation of IAP:caspase complexes
SMP Pathway Links
SMP IDDescription
SMP005005-oxoprolinase deficiency
SMP001435-Oxoprolinuria
SMP00183Gamma-Glutamyltransferase Deficiency
SMP00501Gamma-glutamyl-transpeptidase deficiency
SMP00015Glutathione Metabolism
SMP00337Glutathione Synthetase Deficiency
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