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MGP000418

UniProt Annotations

Entry Information
Gene Namecaspase 7, apoptosis-related cysteine peptidase
Protein EntryCASP7_HUMAN
UniProt IDP55210
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=P55210-1; Sequence=Displayed; Name=Beta; IsoId=P55210-2; Sequence=VSP_000807; Note=Lacks enzymatic activity.; Name=Alpha'; Synonyms=Beta; IsoId=P55210-3; Sequence=VSP_000806; Note=What we call isoform Alpha' is also known as Beta. {ECO:0000305|PubMed:9070923}; Name=4; IsoId=P55210-4; Sequence=VSP_045325;
Catalytic ActivityStrict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val- Asp-|-.
Enzyme RegulationInhibited by isatin sulfonamides.
FunctionInvolved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
InteractionQ13490:BIRC2; NbExp=2; IntAct=EBI-523958, EBI-514538; Q13177:PAK2; NbExp=6; IntAct=EBI-523958, EBI-1045887; P17405:SMPD1; NbExp=6; IntAct=EBI-523958, EBI-7095800; P98170:XIAP; NbExp=2; IntAct=EBI-523958, EBI-517127;
PtmCleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. {ECO:0000269|PubMed:8755496}.
SimilarityBelongs to the peptidase C14A family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHeterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. {ECO:0000269|PubMed:11701129, ECO:0000269|PubMed:15200957}.
Tissue SpecificityHighly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
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