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MGP000425

UniProt Annotations

Entry Information
Gene Namecatalase
Protein EntryCATA_HUMAN
UniProt IDP04040
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 H(2)O(2) = O(2) + 2 H(2)O. {ECO:0000255|PROSITE-ProRule:PRU10013, ECO:0000269|PubMed:7882369}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413;
CofactorName=NADP(+); Xref=ChEBI:CHEBI:58349;
DiseaseAcatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. {ECO:0000269|PubMed:2308162}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionOccurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. {ECO:0000269|PubMed:7882369}.
PtmThe N-terminus is blocked.
SimilarityBelongs to the catalase family. {ECO:0000305}.
Subcellular LocationPeroxisome.
SubunitHomotetramer.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cat/";
Web ResourceName=Wikipedia; Note=Catalase entry; URL="http://en.wikipedia.org/wiki/Catalase";
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